In Vivo Effects of Naringenin and Lead on Rat Erythrocyte Carbonic Anhydrase Enzyme
Journal Title: Turkish Journal of Pharmaceutical Sciences - Year 2017, Vol 14, Issue 1
Abstract
Objectives: Carbonic anhydrase (CA) enzyme catalyses the reversible reactions of CO2 with water and takes part in metabolically important events such as systemic acid-base regulation and respiration. In this study, in vivo effects of lead, which is a heavy metal and to which living beings are exposed by different ways, with naringenin, a flavanone, were investigated. Materials and Methods: For this purpose, four different rat groups were established and one of them was chosen as the control group. The other three groups were given lead, naringenin and lead+naringenin substances to analyze the changes in the CA enzyme of rat erythrocytes. Results: The research findings showed that the enzyme activity in the control group was higher than that in the other groups. The naringenin group showed the highest inhibition effect, while the lead group showed the lowest inhibition. Conclusion: Therefore, it can be said that naringenin is a strong inhibitor of the CA enzyme.
Authors and Affiliations
Müslüm KUZU, Ahmet ÖZKAYA, Zafer ŞAHİN, Üzeyir DAĞ, Veysel ÇOMAKLI, Ramazan DEMİRDAĞ
Keywords
Related Articles
- EP ID EP380912
- DOI 10.4274/tjps.13008
- Views 165
- Downloads 0
Design and In Vitro Evaluation of Eudragit-Based Extended Release Diltiazem Microspheres for Once- and Twice-Daily Administration: The Effect of Coating on Drug Release Behavior
Objectives: The aim of this investigation was to develop an extended release formulation of diltiazem hydrochloride (DL) for once- and twice-daily administration, based on Eudragit (Eud) RL and RS microspheres using emul...
Flavonoid Glycosides from Heracleum pastinaca Fenzl
Objectives: The objective was to isolate and characterize the secondary metabolites of Heracleum pastinaca, which has not been previously investigated. Materials and Methods: Conventional chromatographic procedures were...
Spectrophotometric Quantification of Anti-inflammatory Drugs by Application of Chromogenic Reagents
Objectives: Simple, specific, accurate, precise, sensitive, and cost effective spectrophotometric methods were developed and validated for quantification of the drugs lornoxicam (LOR) and mesalamine (MES) in pure form an...
The Anticancer and Anti-inflammatory Effects of Centaurea solstitialis Extract on Human Cancer Cell Lines
Objectives: Natural products originating from plants have been used for many years in the treatment of various diseases, including cancer. Centaurea solstitialis subsp. solstitialis is used in Turkish folk medicine. This...
Some New Hydrazone Derivatives Bearing the 1,2,4-Triazole Moiety as Potential Antimycobacterial Agents
Objectives: The aim of this study was to synthesize, characterize, and screen some new 1-(4-((2-(4-substitutedphenyl)hydrazono)methyl)phenyl)-1H-1,2,4-triazole derivatives for their antimycobacterial activities. Material...