In Vivo Functional Assessment of Myelin Repair, Inflammatory Response and Marker Genes Expression under Hesperetin NanoParticles Treatment in Local Demyelination Model
Journal Title: The 2nd Annual Meeting of International Center for Neuroscience Research - Year 2021, Vol 2, Issue 1
Abstract
Multiple sclerosis (MS) is one of the most inflammatory disease in worldwide. Demyelination and disturbance of action potential conductance are regarded as main signs of MS. Our recent report demonstrated that hesperetin (Hst) as a citrus flavonoid, significantly reduces the demyelination level in optic chiasm of rats. In this study, the effects of nano-Hst on latency of visual signals, demyelination levels, glial activation, and expression of Olig2 and MBP were evaluated in lysolecithin (LPC)-induced demyelination model. Focal demyelination was induced by injection of LPC (1%, 2 mu L) into the rat optic chiasm. Animals received oral administration of nano-Hst at dose of 20 mg/kg for 14 or 21 days post LPC injection. Visual evoked potential (VEP) recording showed that nano-Hst reduces the latency of visual signals and ameliorates the extent of demyelination areas and glial activation. Expression levels of the Olig2 and MBP were also significantly increased in nano-Hst treated rats. Overall, our data suggest that nano-Hst reduces the latency of visual signals through its protective effects on myelin sheath, amelioration of glial activation, and enhancement of endogenous remyelination.
Authors and Affiliations
Saeideh Baradaran, Akbar Hajizadeh Moghaddam*, Maryam Ghasemi Kasman
Keywords
Related Articles
- EP ID EP701733
- DOI -
- Views 93
- Downloads 0
The Beneficial Potential of Human Dental Pulp Stem Cells and their Conditioned Medium in the Treatment of Rat Model of Ischemic Stroke
Dental pulp stem cells (DPSCs) are considered as a promising type of stem cells for cell-based therapies. Hence, in this study we assessed the therapeutic effects of human (h)DPSCs and their conditioned medium (CM) in a...
Relationship between Dominant Behaviour Model and Psychological Capital with Individual Entrepreneurial Components to Present a Model
Background and purpose: The purpose of this study was to investigate the relationship between psychological capital and behavioral model and the relationship between these two components with the entrepreneurial compon...
The Effect of Hydralazine on Early Stage Alzheimer’s Disease: A Randomized Clinical Trial (EHSAN)
Objective: Hydralazine significantly delays the progression of Alzheimer's disease compared with placebo. Study population and sampling method: The study population in this study are all patients who have a possible di...
Decoding Selective Attention and Cognitive Control Processing through the Stroop Interference Effect: An Event-Related Electroencephalography-Derived Study
Background: The process of cognitive control and resultant selective attention constructs the very shared root of a continuum of neurocognitive functions. Efficient inhibition of the task-irrelevant information and unwa...
Non-Invasive Brain Stimulation Improves Episodic Memory by Recovering Bloodbrain-Barrier Leakage in intracerebroventricular Streptozotocin Injected Rat Model of Alzheimer’s Disease
Intracerebroventricular streptozotocin (STZ) injection at 3mg/kg of b/w is reported to induce Alzheimer disease (AD) like pathology (Frölich et al., 1999; Lannert & Hoyer, 1998; Nitsch & Hoyer, 1991; Salkovic-Petrisic e...