Increased Galectin-3 Levels Predicts Ventricular Arrhythmic Events Following ST-elevation Myocardial İnfarction
Journal Title: Journal of Ankara University Faculty of Medicine - Year 2020, Vol 73, Issue 2
Abstract
Objectives: We aimed to determine the association between Galectin-3 (Gal-3) levels and microvolt T-wave alternans (MTWA) and frequent premature ventricular complexes (PVCs) in single-vessel patients with left ventricular ejection fraction (EF) (LVEF) >35%, who presented with STelevated myocardial infarction (MI) (STEMI) and were treated with primary percutane-ous coronary intervention (pPCI). Materials and Methods: A total of 81 patients were included in this cross-sectional study. Blood samples for Gal-3 levels were obtained from all patients at the time of admission. The patients were separated into low and high Gal-3 (≤ and >1.93 ng/dL, respectively) groups. Low-Gal-3 and high-Gal-3 groups were compared with respect to both MTWA and PVC positivity and their association with Gal-3 levels were examined. Results: When compared to the low-Gal-3 group, left atrial volume (LAV) was higher in the high-Gal-3 patients (55.7±18.0 vs 40.6±13.7 mL, p<0.001). Multivariate analyses revealed that age, LAV and Gal-3 levels were significant independent predictors of PVC positivity (p=0.005, p=0.04, p=0.002, respectively); and Gal-3 was a significant independent predictor of MTWA positivity (p=0.002). Conclusion: Gal-3 was associated with PVC and MTWA positivity, and was a predictor of arrhythmic events in single-vessel STEMI patients with LVEF >35%.
Authors and Affiliations
İsmail Bolat, Hamdi Pusuroğlu
Keywords
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- EP ID EP684817
- DOI 10.4274/atfm.galenos.2020.86548
- Views 152
- Downloads 0
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