Increased TG/HDL Ratio, A Surrogate Marker of Insulin Resistance In PCOS Women
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 11
Abstract
Background: Insulin resistance (IR) is an important clinical and biochemical determinant, not only for diabetes but also of many other clinical states including polycystic ovarian syndrome. TG/HDL ratio has been a simple and reliable marker of insulin resistance. Hence TG/HDL ratio was analyzed to assess the degree of insulin resistance in women with Poly Cystic Ovarian Syndrome. Methods: Total of 60 patients diagnosed as PCOS by Rotterdam criteria (mean age 23.8±4.18) and 35 healthy subjects (mean age 24.06±4.01) were enrolled for this study. Anthropometric measurements, glucose levels, insulin levels and lipid profile were measured in all these subjects. TG/HDL ratio, Homeostasis model of assessment of IR (HOMA-IR) and Quantitative Insulin check index (QUICKI) were then calculated. Results: PCOS women had a higher BMI with increased Total Cholesterol, TGL, LDL, VLDL, HOMA-IR value and a lower HDL and QUICKI check index when compared to the control group which was statistically significant (p<0.001). There was no significant difference in Plasma glucose level among the groups. Women with PCOS showed a significantly higher TGL/HDL ratio and significant positive correlation with HOMA-IR (r=0.4, p<0.001) and negative correlation with QUICKI check index (r=-0.41, p<0.001). Conclusion: TG/HDL ratio is strongly associated with insulin resistance in PCOS women .So it could be a less expensive, reliable marker for assessment of insulin resistance in PCOS women.
Authors and Affiliations
G. Hariprasath, Dr. S. Sakila, Dr. K. Lavanya Kumari
Keywords
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- EP ID EP249543
- DOI 10.9790/0853-1611102932
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