Incretion based therapy for type 2 diabetes mellitus
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2014, Vol 11, Issue 3
Abstract
Most existing antidiabetic agents target only one aspect of the pathophysiology of T2DM, and neither tackle the progressive deterioration in beta-cell mass and function nor the hyperglucagonemia that accompanies T2DM. In contrast, incretin-based approaches target both alpha- and beta-cell dysfunction. Studies indicate that incretin-based therapies perhaps because of the potential trophic effects on the pancreatic beta-cells - may halt the progression of disease that inevitably seems to accompany conventional treatment Within the next year many new and promising GLP-1 analogs and DPP4 inhibitors will be introduced to the market, and, the future will elucidate whether these will have the potential of being disease-modifying drugs.
Authors and Affiliations
Akash Khobragade , Sadiq Patel , Nagsen Ramraje , Ranjit Mankeshwar , Sagar Bhagat , Abhijit Bhagat
Keywords
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