Indium chloride (InCl3) catalysed domino protocol for the regioselective synthesis of highly functionalized pyranopyrazoles under mild conditions
Journal Title: Iranian Chemical Communication - Year 2017, Vol 5, Issue 1
Abstract
Regioselective synthesis of highly functionalized pyranopyrazoles was achieved in excellent yield from phenyl pyrazolone, substituted aromatic aldehyde with nitroketene-N,S-acetal in the presence of indium trichloride as a versatile catalyst under reflux condition in ethanol-water mixture. All reactions preceeded within a short period of time with excellent purity. All of the synthesized compounds were identified by IR, 1H NMR, 13C NMR and mass spectroscopy. Quantitative yields, inexpensive and environmentally friendly solvent system and simple work-up procedure are the attractive features of the present method. It is thus enviro-economic method without producing hazardous wastes. The formed pyranopyrazoles might find to possess important biological and pharmaceutical applications.
Authors and Affiliations
Dattatray N. Survase, Hemant Vilas Chavan, Sakharam B. Dongare, Shreeram D. Ganapure, Vasant B. Helavi
Keywords
Related Articles
- EP ID EP259743
- DOI -
- Views 133
- Downloads 0
An Efficient One-Pot Green Synthesis of 4H-Benzo[b]pyrans Using Guanidinium Chloride as Polyfunctional Organocatalyst
A simple, efficient, and high yielding one-pot protocol has been developed for the synthesis of 4H-benzo[b]pyrans scaffolds installing a three-component tandem Knoevenagel-cyclocondensation reaction of an aldehyde, malon...
Design, synthesis and anticancer evaluation of novel thiazine, pyrimidine and pyridine derivatives
Acylisothiocyanate (1) was allowed to react with benzylidene malononitrile producing oxazine derivative (2). Also, compound (1) was reacted with sodium azide followed by refluxing with sodium ethoxide affording thiazinot...
Extraction and preconcentration of Pb(II) from water and soil samples using modified activated carbon
In this work, a new extractant was prepared by immobilizing ligand 2-(5-bromo-2-pyridylazo)-5-diethylaminophenol, (5-Br-PADAP), on the activated carbon and applied to extraction of Pb(II) prior to determination by flame...
Experimental study of the effect of undoped ZnO, Fe and Mn doped ZnO nanostructures and the electrochemical response of the nanostructured modified carbon paste electrode toward Levodopa
In this study, undoped ZnO and doped with Fe and Mn nanostructures were synthesized by hydrothermal method. The morphology of nanostructures was characterized by Scanning Electron Microscope. The electrochemical response...
Synthesis, Characterization and interaction Studies of 1-(3-bromophenyl azo) 2,7-dihydroxy naphthalene, (BPADHN) with calf thymus deoxy ribo nucleic acid (ct-DNA)
In this study at first , an azo dye, 2,7- naphthalenediol, 2-[(4-Bromophenyl)azo (BPAND) as a ligand has been synthesized by addition of p-Bromoaniline to the modified montomorillonite K10 clay. This ligand was character...