Tetrabutylammonium bromide-Cesium carbonate: new reagent system for the synthesis of substituted pyridines at room temperature
Journal Title: Iranian Chemical Communication - Year 2016, Vol 4, Issue 2
Abstract
The highly substituted pyridine derivatives are found to exhibit diverse pharmacological activities. They are also emerged as potential medicinal leads in developing therapeutic agents for the treatment of various diseases. In this work, a series of 2-amino-3,5-dicarbonitrile-6-thio-pyridine derivatives have been synthesized at room temperature via one-pot, multi-component reaction of various aromatic aldehydes, malononitrile and thiophenols using catalytic amount of tetrabutylammonium bromide (TBAB) and cesium carbonate in methanol. In the present method, the use of thermal condition is avoided. In addition, the advantages such as operational simplicity, economic viability, ecologically benign nature make this protocol a very efficient alternative to the literature methods.
Authors and Affiliations
Vinod Kamble, Sandeep Atkore, Parshuram Pisal, Munazza Sadaf, Renuka V. Thakre
Synthesis, spectroscopic investigation and coductometry of a new hexadentate symmetric Schiff base ligand containing N2O2S2 donor atoms and related complexes with Cd(II), Zn(II), Co(II) and Mn (II) metal ions
In this paper, we report the synthesis and characterization of a new symmetric macroacyclic Schiff base ligand (H2L) and related complexes with different metals. (H2L) was synthesized by the one pot condensation reaction...
Fabrication of new carbon paste electrodes based on gold nano-particles self-assembled to mercapto compounds as suitable ionophores for potentiometric determination of Copper ions
In the present study, we investigate the potentiometric behavior of Cu2+ carbon paste electrodes based on two mercapto compounds 2-Ethylmino-5-Mercapto-1,3,4-Thiadiazole (EAMT) and 2-Acetylamino-5-mercapto-1,3,4-thiadiaz...
A theoretical study on quadrupole coupling parameters of HRPII Protein modeled as 310-helix & α-helix structures
A fragment of Histidine rich protein II (HRP II 215-236) was investigated by 14N and 17O electric field gradient, EFG, tensor calculations using DFT. This study is intended to explore the differences between 310-helix an...
Surfactant-assisted synthesis of Barium hexaferrite nanoparticles by hydrothermal method
In the present work, the synthesis of Barium hexaferrite (BaFe12O19) nanoparticles in the presence of a large excess amount of OH− anions by the hydrothermal method in the presence and absence of surfactants such as Sodi...
Synthesis and characterization of some polymer derivatives of carvacrol as drug delivery system
Carvacrol is one of the main components of the EO of some Labiatae (Laminaceae) members like oregano, thyme and savory. Carvacrol has a lot of health benefits for example, antibacterial, and antioxidant activity.We synth...