Induced pluripotent stem cells: An update
Journal Title: International Journal of Blood Transfusion and Immunohematology - Year 2015, Vol 5, Issue 1
Abstract
Introduction: The discovery that the mature cells can be reprogrammed to become pluripotent increased the enormous interest in induced pluripotent stem cell (iPSC) technology for their potential application in biomedical sciences. The breakthrough research offering induction of pluripotent status in somatic cells by direct reprogramming depends upon the genes used for induction. The induced pluripotent stem cells share features with embryonic stem cells such as pluripotency and immortality. The iPSC technology opened new avenues and provided vast opportunities for regenerative therapy and therapeutic drug development. This review summarizes the developments in iPSC technology highlighting the generation of iPSCs from blood as a source, which is a very important finding, alleviating the need for more invasive techniques such as skin punch biopsies.
Authors and Affiliations
Anubha Singh, Deepak Kumar Singh, Usha Bhoria
Keywords
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- EP ID EP209978
- DOI 10.5348/ijbti-2015-16-RA-2
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