Inflammatory Myofibroblastic Tumour of Lung, Masquerading As Tuberculosis – A Case Report
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 2
Abstract
Inflammatory myofibroblastic tumor is a histologically distinctive lesion that occurs primarily in the viscera and soft tissue of children and young adults. It is considered a tumor of borderline malignancy because of its tendency to recur locally (at least at certain sites) and its ability to metastasize rarely. It is composed of a variable mixture of collagen, inflammatory cells, and usually cytologically bland spindle cells showing myofibroblastic differentiation. There are many uncertainties about the pathogenesis of IMT. Currently, surgery is the mainstay of the treatment for IMTs. It has three histological subtypes. The differential diagnosis of this lesion depends on the clinicopathologic setting, including the patient’s age, gender, tumor location, and number of lesions. Rarely inflammatory myofibroblastic tumors have a conspicuous population of large multinucleated tumor cells with prominent nucleoli bearing a resemblance to the Reed-Sternberg cells of Hodgkin’s disease. Based on the two largest studies of abdominal and retroperitoneal lesions, it is clear that tumors in this location have a propensity for more aggressive behavior than their extra-abdominal counterparts, with recurrence rates of 23% to 37%.
Authors and Affiliations
Maulik Monpara, Anjali Patrikar, Sabiha Maimoon, Anne Wilkinson, Ketan Mhatre
Keywords
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