INFLUENCE OF A PECTIN ON THE PROPERTIES OF HYDROPHILIC POWDERS CONTAINING A LACTIC ACID-CHITOSAN COMPLEX
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2017, Vol 0, Issue
Abstract
Gynecological powders are designed to correct abnormal pH environments of the vagina and the stabilise the pH to the physiological state 3.5-5.0. Powders were transformed into gels and were tested for their properties. Formulations were prepared with varying pH and rheological properties. The test showed the work of adhesion of gels. All gels with ratios of 1:1 and 2:1 of lactic acid to chitosan showed a pH in the physiological range at 37°C. Additional pectin and excipients allows various formulations with a wide range of pH to be obtained. Rheological investigation revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and pectin in comparison to the gels without pectin. Studies of work of adhesion showed the effect of glycerol, 1,2-propylene glycol and their concentration on the value of the work of adhesion. The results obtained in the experimental studies demonstrated that it is possible to produce a preparation with optimal pharmaceutical and application properties.
Authors and Affiliations
Katarzyna Małolepsza-Jarmołowska
Keywords
Related Articles
- EP ID EP320693
- DOI 10.15259/PCACD.22.13
- Views 60
- Downloads 0
VISCOMETRIC STUDIES OF MICROCRYSTALLINE CHITOSAN/POLY(VINYL ALCOHOL) MIXTURES
In the present paper, the results of viscosity measurements in dilute solutions of microcrystalline chitosan (MCCh) with poly(vinyl alcohol) (PVA) of different degrees of hydrolysis are presented. Microcrystalline chitos...
Studies on the Dyeing of Chitin and Chitosan with pre-metallised Dyes at Neutral pH
Both 1:1 pre-metallised acid dyes and pre-coppered direct dyes, but not 1:2 pre-metallised acid dyes, have been shown to readily dye chitin and chitosan from neutral dyebaths. With the 1:1 pre-metallised acid dyes the ad...
EVALUATION OF PREPARATIONS PHARMACEUTICAL SALAZOSULFAPIRIDIN DEPENDING USED FOOD SUPPLEMENTS CONTAINING CHITOSAN IN MODEL “IN VITRO”
An increase in sulfasalazine absorption on a polymer at increasing pH from 7.6 to 8.0 may be explained by the swelling properties of chitosan, which forms a conglomeration in the form of emulsion system. Basing on the ab...
THE ROLE OF OLIGOCHITOSANS IN AKT KINASE REGULATION
Among characteristic properties of cancers, there is their increased glycolytic activity.Contrary to normal cells, neoplastic cells use anaerobic glycolysis, even when a sufficient amount of oxygen is available. The inte...
PROCESS OF CONTINUOUS PRODUCTION OF OLIGOAMINOSACCHARIDES IN A COLUMN REACTOR
A continuous production of oligoaminosaccharides from chitosan was achieved with a column reactor packed with chitosanolytic enzymes-containing mycelia of Mucor circinelloides and Mucor racemosus immobilized in porous ca...