INFLUENCE OF A PECTIN ON THE PROPERTIES OF HYDROPHILIC POWDERS CONTAINING A LACTIC ACID-CHITOSAN COMPLEX
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2017, Vol 0, Issue
Abstract
Gynecological powders are designed to correct abnormal pH environments of the vagina and the stabilise the pH to the physiological state 3.5-5.0. Powders were transformed into gels and were tested for their properties. Formulations were prepared with varying pH and rheological properties. The test showed the work of adhesion of gels. All gels with ratios of 1:1 and 2:1 of lactic acid to chitosan showed a pH in the physiological range at 37°C. Additional pectin and excipients allows various formulations with a wide range of pH to be obtained. Rheological investigation revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and pectin in comparison to the gels without pectin. Studies of work of adhesion showed the effect of glycerol, 1,2-propylene glycol and their concentration on the value of the work of adhesion. The results obtained in the experimental studies demonstrated that it is possible to produce a preparation with optimal pharmaceutical and application properties.
Authors and Affiliations
Katarzyna Małolepsza-Jarmołowska
Keywords
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- EP ID EP320693
- DOI 10.15259/PCACD.22.13
- Views 90
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