Influence of non-alcoholic fatty liver disease on the cardiac hemodynamics indices and vascular disorders in patients with essential hypertension
Journal Title: Сучасна гастроентерологія - Year 2018, Vol 0, Issue 2
Abstract
Objective — to compare the structural and functional state of the heart, vessels and liver in patients with isolated EH and in conditions of its combination with NAFLD. Materials and methods. A total of 117 patients with NAFLD with EH stage II, 2 degree were examined in the LT Malaya National Institute of Therapy of the NAMS of Ukraine, from them 63 were men (53.86 %) and 54 women (46.14 %). The mean age was 54.4 ± 5.9 years. Thepatients were allocated into groups depending on the NAFLD presence and the NAFLD fibrosis score (NFS). Group 1 consisted of 74 patients with EH and NAFLD with NFS ≥ –1.455; group 2 included 43 patients with EH and NAFLD with NFS < –1.455; group 3 comprised 30 patients with isolated EH. The control group consisted of 20 practically healthy persons. Results. It has been established that structural and functional disorders of the heart and arteriesare specific for patients with NAFLD and EH. In contrast to the subjects with EH in combination with NAFLD without liver fibrosis and isolated EH, patients with NAFLD and liver fibrosis had significantly higher values of the thickness of intimamedia complex of the carotid arteries (CIM), LV myocardial mass ratio (LVMMR), left ventricular diastolic filling factor E/e. The preserved LV systolic function and prognostically unfavorable concentric (55.4 %) and eccentric (43.8 %) LV hypertrophy were specific for the patients with comorbidity of EH and NAFLD with liver fibrosis. The presence of significant direct correlation (rs = +0.34) between the level of NFS and LVMMR has been established, that proved the effects of the progression of liver damage on the LVHprogression in patients with NAFLD and EH; and significant direct correlation (rs = +0.28) between NFS and CIM.The significant reverse correlations were found between the NFS and E/e (rs = – 0.32), the NFS and endotheliumdependent vasodilation (EDVD) (rs = –0.31), which indicatedthe relationship between the presence and degree of hepatic fibrosis with the condition of the arteries in patients with comorbidity of NAFLD and EH. Conclusions. Patients with comorbidity of EH and NAFLD with liver fibrosis are characterized by the increasedvalues of carotid CIM, LVmyocardial mass ratio, the integral index of the LV diastolic filling E/e. The vascular wall alterations in these patients manifested in more intensive CIM thickening and decrease of the degree of endotheliumdependent vasodilation of brachial arteries in comparison with the patients with isolated EH.
Authors and Affiliations
K. О. Prosolenko, V. I. Molodan, A. S. Shalimova
Keywords
Related Articles
- EP ID EP294147
- DOI -
- Views 127
- Downloads 0
Pancreatic fibrogenesis: modern concepts
Pancreatic stellate cell (PSC) is a type of pluripotent cell located between pancreatic lobules and the surrounding area of acinus. At rest (non-activated state), PSCcytoplasm contains the reserve of vitamin A (retinoids...
The pilot study of the awareness of students and tutors about gastroesophageal reflux disease
Objective — to conduct an analysis of the awareness of the students and tutors regarding gastroesophageal reflux disease (GERD) and to determine the disease prevalence among them with the use of questionnaires. Material...
New directions in the treatment of irritable bowel syndrome: focus on microbiosis
Fecal transplantation (FT) is the process of transplanting purified fecal material from a healthy donor to a recipient. The available evidence confirmed the positive role of FT in the treatment of a number of diseases, i...
A clinical case of eosinophilic esophagitis combined with macroamylasemia
Eosinophilic esophagitis is one of the most prevalent esophageal diseases and the leading cause of dysphagia and food impaction in children and young adults. The authors presented a clinical case of a patient with eosino...
Modern approaches to the treatment of combed non-alcoholic fatty liver disease and cardiovascular disease
Non-alcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease and it progresses from simple steatosis to steatohepatitis, fibrosis and cirrhosis. It has been proven that NAFLD is a multisystem disea...