Influence of oxcarbazepine and its combination with SIB-1893 on body temperature in rats
Journal Title: Journal of Pre-Clinical and Clinical Research - Year 2008, Vol 2, Issue 1
Abstract
The aim of the study was to determine the effects of oxcarbazepine (OXC – a newer antiepileptic drug) administered alone and in combination with SIB-1893 (a selective non-competitive metabotropic glutamate subtype 5 [mGlu5] receptor antagonist) on body temperature in freely moving rats. Temperature was monitored using programmed microchips, implanted subcutaneously in Wistar rats, at several time intervals: 0, 5, 10, 20, 30, 45, 60, 90, 120 and 180 min. after intraperitoneal administration of OXC, SIB-1893, and their combination. Statistical evaluation of data with two-way ANOVA with repeated measure on time revealed that SIB-1893 at a dose of 30 mg/kg significantly decreased the body temperature in rats at times ranging from 90-180 min. after drug administration. In contrast, OXC at a dose of 5 mg/kg, administered alone and in combination with SIB-1893 (30 mg/kg), did not significantly alter the body temperature in freely moving rats. Based on this pre-clinical study, one can conclude that OXC administered alone and in combination with SIB-1893 have no effect on body temperature in rats up to 180 min. after intraperitoneal administration of the drugs.
Authors and Affiliations
Jarogniew Łuszczki, Kinga Borowicz, Stanisław Czuczwar
Keywords
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