Fatty acid composition in cerebral cortex, hippocampus and cerebellum in adult rats receiving salmon oil for 6 months
Journal Title: Journal of Pre-Clinical and Clinical Research - Year 2014, Vol 8, Issue 1
Abstract
[b]Introduction.[/b] Polyunsaturated fatty acids (PUFA) play an important role in the functioning of the brain, particularly in childhood and old age. The diet of pregnant mothers as well as very young children, affects the composition of fatty acids in childrens’ brains and suggests the question of whether a diet enriched in n-3 PUFA throughout adult life may result in elevated levels of PUFA n-3 in individual brain regions, and thus delay the aging process. [b]Objective.[/b] The purpose of this research was to establish the fatty acid composition in the cerebral cortex, hippocampus and cerebellum in adult rats receiving for 6 months salmon oil, which is a rich source of n-3 fatty acid. [b]Materials and method.[/b] 6-week-old rats were acclimatized for 2 weeks and then assigned into 2 groups (n=10): control and fish oil supplemented. Both control and supplemented animals were fed a semi-synthetic, isoenergetic diet that varied only in fat composition. The brain fatty acids profile was determined by gas-chromatography analysis. [b]Results. [/b]Rats fed the supplemented diet showed an increased level of 22:6n-3 and a decreased level of 20:4n-6 and C22:5n-6 in all brain regions when compared to the control group. Furthermore, there was an increase of all monounsaturated fatty acids (MUFA) only in the hippocampus of supplemented rats when compared to the control group. Saturated fatty acids (SFA) content was only slightly modified in the administered diets. [b]Conclusions[/b]. A diet rich fish oil can restore an adequate level of fatty acid in the aging brain.
Authors and Affiliations
Maciej Firląg, Piotr Ostaszewski, Bożena Balasinska
Keywords
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