Inherited Thrombophilia, Cerebral Infarction, and Pregnancy
Journal Title: Journal of Neurological Sciences-Turkish - Year 2006, Vol 23, Issue 2
Abstract
Inherited thrombophilia is a familial disorder that can be particularly seen in young patients causing venous thrombosis. While it is rarely seen in aterial thrombosis, the addition of another risk factors such as –especially- pregnancy must lead to a throughout etiological examination, and inherited thrombophilia should be considered regardless of a family history or a previous arterial/venous infarction. 32-year-old pregnant female patient admitted to our neurology department complaining of numbness on left hand for one week. Her neurologic examination revealed no abnormality except hypoesthesia in the same side. Cranial magnetic resonance imaging showed right thalamic infarction. Etiological laboratory investigations revealed a-protein S deficiency. The patient was diagnosed as hereditary thrombophilia. After that, the same diagnosis was established in her 11-year-old first daughter who never had a thromboembolic disease. The patient, admitted at the end of first trimester, was put on low-molecular-weight heparin (Nadroparine 0.6ml/day). Anticoagulation therapy was continued during her pregnancy without complication, but protein C and S deficiency was detected in her newborn daughter as well. Genetic testing showed a positive heterozygout inheritance. Hereditary thrombophilia increases the risk of fetal loss and possibly other serious obstetric complications. During the pregnancy all women with cerebral infarction should be investigated for inherited thrombophilia regardless of a family history or a previous arterial/venous infarction and accurate treatment should be made.
Authors and Affiliations
Derya ULUDUZ, Melda BOZLUOLCAY, Birsen INCE
Keywords
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