Influence of Altiazem PP-180 on Hemodynamic Parameters in Arterial Hypertension Patients under Outpatient Conditions
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2017, Vol 6, Issue 10
Abstract
The aim of this research work is to study the effect of altiazem PP-180 on hemodynamic parameters in 78 II-degree arterial hypertension patients under outpatient conditions. Hemodynamic effect of altiazem PP-180 hypotensive action was successfully observed at 07.00 a.m., 10.00 a.m. and 10.00 p.m. intake time, with normal patients’ routine. Altiazem PP-180 causes a distinct hypotensive effect in II-degree arterial hypertension patients when used under outpatient conditions at different times of a day both fxed or random. The most productive hemodynamic effect of altiazem PP-180 hypotensive action can be observed when taken at 07.00 a.m., 10.00 a.m. and 10.00 p.m. provided that a normal work/rest routine is kept. When administered at 07.00 a.m., 10.00 a.m. and 10.00 p.m., altiazem PP-180 causes substantial decrease of peripheral vascular resistance, end-diastolic and end-systolic volumes. Hypotensive effect of altiazem PP-180, when administered at 01.00, 04.00 and 07.00 p.m. as well as at non-fxed times of day shows a less favourable hemodynamic effect: reduced cardiac output associated with total and peripheral vascular resistance index.
Authors and Affiliations
GR Zhakiyeva| Associate Professor and HOD, General Practice of Internship and Postgraduate Training, West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan Corresponding e-mail: gulzhahan.zhakieva@list.ru, LM Tulegenova| Professor, Department of General Practice of Internship and Postgraduate Training, West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan, NZ Ibragimova| Assistant Professor, Department of General Practice of Internship and Postgraduate Training, West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan, SM Kelimberdiyev| Professor, Department of General Practice of Internship and Postgraduate Training, West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan, KK Tokbayeva| Assistant Professor, Department of General Practice of Internship and Postgraduate Training, West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan
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