Insights into Mefenamic Acid-Induced Allergic Reactions: A Comprehensive Clinical and Research Review
Journal Title: Open Access Journal of Pharmaceutical Research - Year 2024, Vol 8, Issue 1
Abstract
This study investigates the incidence of Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome associated with the over-the-counter non-steroidal anti-inflammatory drug (NSAID) mefenamic acid. Approximately 10% of individuals exposed to mefenamic acid experience DRESS syndrome, a severe and potentially fatal allergic reaction characterized by fever, skin rash, lymphadenopathy, hematological abnormalities, and internal organ involvement. Leukocytosis with eosinophilia (90%) and mononucleosis (40%) has been linked to certain cases, emphasizing the diversity of clinical presentations. The causative medication must be promptly discontinued upon identification of DRESS syndrome, with documented evidence indicating improved prognosis with early drug removal. Despite the severity of these reactions, the study sheds light on the alarming accessibility of mefenamic acid and other banned medications in developing nations, particularly exemplified by the Indian Pharmacopoeia Commission’s alert on mefenamic acid issued on December 7, 2023. The lack of effective law enforcement and medical awareness poses significant challenges, allowing banned drugs, including Nimesulide and Rofecoxib, to persist in the market despite being banned by the USFDA. This research underscores the critical need for global collaboration to address regulatory gaps, enhance medical awareness, and enforce stringent measures to restrict the availability of harmful medications in developing nations. Urgent attention to these issues is imperative to safeguard public health and ensure the effective implementation of drug regulations on a global scale.
Authors and Affiliations
Rutuja D*, Dimpal D, Ganesh S, Piyush B, Rushikesh B, Kajal P and Dhananjay P
Keywords
Related Articles
- EP ID EP751866
- DOI 10.23880/oajpr-16000295
- Views 24
- Downloads 0
Antifungal Drugs Loaded Nanosponges to Improve Bioavailability of Antifungal Drugs; A Review
Fungal infections have become a major concern in this era for human health leading to morbidity and mortality. A lot of antifungal agents are available for treatment, with poor therapeutic outcomes due to poor bioavaila...
In Vitro Antimicrobial Activity of Chlorine Effervescent Tablets against Some Pathogenic Bacteria and Fungi
Objectives: The objective of the present study was to evaluate the antimicrobial activity of available choline (sodium dichloroisocyanurate (NaDCC) ) effervescent tablet solutions. Methods: Four bacteria and one fungi...
Exploring the Interplay of Socio-Demographic Factors, Medication Preferences, and Adherence Behaviors in Candidiasis Treatment Outcomes in Ghanaian Females
Introduction: Candidiasis, a fungal infection caused primarily by Candida species, affects millions of people worldwide, particularly women. Despite the availability of antifungal treatments, treatment failures remain a...
Analgesic and Anti-inflammatory Properties of Argyreia Pilosa Wight & Arn
Background: Pain and inflammation are usually related to the pathophysiology of several medical conditions. The majority of antinociceptive and anti-inflammatory medications accessible within the merchandise found an out...
Review on Novel Monoamine Oxidase Inhibitors: A Clinician’s Guide
The purpose of this review is to provide information on the mechanisms of action, pharmacokinetics, therapeutic effectiveness, safety, and tolerability of four novel antidepressants: pirlindole, safinamide, selegiline,...