Insulin Resistance in Polycystic Ovary Syndrome
Journal Title: PARIPEX-Indian Journal of Research - Year 2015, Vol 4, Issue 6
Abstract
Polycystic ovary syndrome (PCOS) is a common endocrine disease with metabolic, reproductive and psychological consequences effecting reproductive age women. In addition to the clinical features of oligo-anovulation, infertility and hyperandrogenism, PCOS is closely interrelated with insulin resistance (IR) and hyperinsulinemia, with a high prevalence. IR is also suggested to have a role in the pathogenesis of PCOS. Post-receptor defects, as well as genetic susceptibility has been held responsible for underlying mechanisms of IR. Assessment of IR includes tests of fasting insulin and blood glucose levels. In especially obese women with PCOS, oral glucose tolerance tests are recommended for screening. To overcome IR, reducing body fat and weight with a healthy diet is the initial step. Therapeutic approach includes insulin-sensitizing agents. The prevention of long-term consequences of IR in PCOS, like cardiovascular disease, type 2 diabetes and endometrium cancer, through appropriate screening, diagnosis and intervention is highly important.
Authors and Affiliations
Kiseli M, Gürsoy AY, Caglar GS
Keywords
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