Interleukin-23, a novel marker in the diagnosis of psoriasis
Journal Title: Medpulse International Journal of Biochemistry - Year 2019, Vol 9, Issue 2
Abstract
Background: In psoriasis, local and systemic cytokines regulation contributes an important role in pathogenesis. Serum IL-23 levels was notably raised in active psoriasis patients, indicating their role in disease pathogenesis and negatively associated with extent of the disorder. Aim: To estimate and assess whether IL-23 is a key specific factor in pathogenesis of psoriasis. Material and Methods: In this case control study, a total of 90 individuals were included and divided into -Group I (Cases): 45 newly diagnosed cases of psoriasis and Group II (Controls): 45 Non-psoriatic healthy individuals with no family history of psoriasis. IL-23 was estimated by ELISA using Sincere kit. Results: The mean value of IL-23 level in controls was 61.47 and for cases 62.26. In the mean value of controls and cases, there was only a little elevation in cases, which was statistically insignificant. Conclusion: In present study, insignificant relationship was found between cases and controls in IL-23 values. This could be due to the study population was selected from low socioeconomic status people, have been relatively associated with elevated levels of inflammatory markers due to their lifestyle.
Authors and Affiliations
T Rameswari, G Ezhil
Keywords
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- EP ID EP521722
- DOI 10.26611/1002928
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