Serum PON-1 activity in the diabetes mellitus patients for predicting the atherogenic risk
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 8, Issue 1
Abstract
Background: PON-1 activity has been demonstrated to be inversely related to the risk of cardiovascular disease and a reduction in PON-1 activity has been reported in states of high oxidative stress such as uncontrolled diabetes. Thus, estimation of serum PON-1 activity in diabetes mellitus is being valuable in predicting atherosclerosis and future cardiovascular events. Aim: To evaluate the serum PON-1 activity in diabetes mellitus for predicting atherogenic risk. Material and Methods: A total of 100 subjects were included in the present study. Out of this 100, 50 were study group (patients with DM) and the other 50 were control group (healthy individuals).PON-1 activity was estimated using the paraoxon (O,O diethyl-O-4 nitrophenyl phosphate) as the substrate for hydrolysis. The chemicals used were of analytical reagent grade from Sigma chemicals. Glucose, urea, creatinine, total cholesterol, HDL cholesterol and Triacylglycerol were estimated. Results: The serum PON-1 activity between the control (270.50±81.11) and study groups (99.19±38.71). There is a highly significant difference between the two groups (p=<0.0001).Both HDL and PON activity are significantly decreased in the study group. Conclusion: PON-1 activity may act as a useful marker for early prediction of atherosclerosis in DM. By predicting earlier, early interventional measures by pharmaceutical means or by dietary means can be done.
Authors and Affiliations
M Ramadevi, S Senthil Kumari
Keywords
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