Interrelationship between endothelial dysfunction, IMT of the carotid arteries and adhesion molecules in obese hypertensive children and adolescents
Journal Title: Endokrynologia, Diabetologia i Choroby Przemiany Materii Wieku Rozwojowego - Year 2007, Vol 13, Issue 1
Abstract
Introduction: Adhesion molecules released by dysfunctional endothelial cells are markers of an early atherosclerotic process. Ultrasonography of the brachial arteries (flow mediated dilatation – FMD) is used to detect an impairment of endothelial vasodilation, whereas the examination of intima-media thickness complex (IMT) of the common carotid arteries detects the earliest structural changes of the vessels. The aim of the study was to define the correlations between biochemical markers of endothelial dysfunction (sICAM-1, sVCAM-1, sE-selectin), vasodilatatory function (FMD) and early atherosclerotic changes (IMT) in children and adolescents with obesity and hypertension. Material and methods: The study group consisted of 85 patients aged 14,6±2,4; of whom 22 obese children, 31 hypertensive children and 32 obese hypertensive children were distinguished. The control group included 26 healthy children. Adhesins concentrations were determined by an immunoenzymatic method (R&D Systems). FMD was assessed via the measurement of flow-mediated dilation of the brachial artery by ultrasound (Hewlett Packard Sonos 1000) according to the method worked out by Celermajer, whereas IMT was evaluated by means of Pignolie’s method. Results: Linear correlation analysis proved a significant positive correlation between sICAM-1 and IMT (r=0,32, p=0,013) and a marked negative correlation between IMT and FMD (r=-0,26; p=0,04) in the whole study group. Analysis carried out in particular groups showed significant correlations only in the group of obese hypertensive children. sICAM-1 concentration correlated markedly positively with IMT (r=0,52; p=0,001) and negatively with FMD (r=-0,37; p=0,027). sE-selectin concentration correlated significantly positively with IMT (r=0,41; p=0,012). In regression models, IMT correlated with sICAM-1 (p=0,03) and BMI (p=0,02), whereas FMD correlated negatively with sICAM-1 (p=0,04). Conclusions: The association between adhesion molecules (sICAM-1, sE-selectin) with impaired vasodilation activity and the early atherosclerotic structural changes in the common carotid arteries were found in obese hypertensive children and adolescents. The coexistence of both risk factors may predispose these young patients to closely related disturbances connected with early atherosclerosis.
Authors and Affiliations
Barbara Głowińska-Olszewska, Joanna Tołwińska, Mirosława Urban
Keywords
Related Articles
- EP ID EP83907
- DOI -
- Views 107
- Downloads 0
Rola polimorfizmu genu FTO w patogenezie otyłości
W patogenezie otyłości biorą udział zarówno czynniki środowiskowe jak i genetyczne. Aktualnie uwaga badaczy jest skupiona na podłożu genetycznym nadmiernej masy ciała. Obecnie uważa się, że istnieje związek między otyłoś...
Prediction of the clinical remission using the C-peptide level in type 1 diabetes in children
The aim of the study was to identify individual, clinical and metabolic factors that predict the C-peptide levels and appearance of clinical partial remission during the first year of type 1 diabetes (T1D) in children....
Ocena gestości mineralnej tkanki kostnej oraz markerów obrotu kostnego u dzieci długotrwale leczonych syntetyczna lewotyroksyna z powodu nietoksycznego wola rozlanego i guzkowego.
Ocena dobowych profilów glikemii uzyskanych przy użyciu systemu ciągłego monitorowania glikemii u dzieci z cukrzycą typu 1 o dobrym wyrównaniu metabolicznym
Wprowadzenie: Skuteczna terapia cukrzycy wymaga utrzymania glikemii w wąskim zakresie ze względu na poważne konsekwencje hiperglikemii pod postacią późnych powikłań, jak i ryzyko ciężkiego niedocukrzenia. Cel ten może by...
Zmiany składu ciała u dzieci z somatotropinową niedoczynnością przysadki w pierwszych dwóch latach leczenia hormonem wzrostu
Wprowadzenie: U dzieci najistotniejszym efektem leczenia hormonem wzrostu (GH) jest zwiększenie szybkości wzrastania, natomiast efekt metaboliczny jest ważny w leczeniu dorosłych pacjentów z somatotropinową niedoczynnośc...