interstitial lung disease in systemic sclerosis, idiopathic inflamatory myopathies, sjögrens syndrome and mixed connective tissue diseases
Journal Title: Postępy Nauk Medycznych - Year 2011, Vol 24, Issue 4
Abstract
The connective tissue diseases are a variable group of autoimmune mediated disorders characterized by multiorgan damage. Interstitial lung disease is a well-recognized manifestation of connective tissue disease. Lung involvement is an increasing cause of mortality and morbidity in the connective tissue diseases. The frequency, clinical presentation, prognosis and response to therapy are different, depending on the pattern of involvement as well as on the underlying connective tissue disease. Pulmonary involvement in systemic sclerosis is very common and became the first cause of death in this disease. Autopsy studies have documented lung involvement in majority of patients. Interstitial lung disease is also well-recognized manifestation of polymyositis and dermatomyositis but its prevalance and natural course are poorly understood. Pulmonary abnormalities are often described extraglandular systemic manifestation of Sjögrens syndrome and mixed connective tissue disease. In this article, interstitial lung disease accompanying systemic sclerosis, idiopathic inflammatory myopathies, Sjögrens syndrome and mixed connective tissue disease are reviewed.
Authors and Affiliations
Małgorzata Bartosiewicz
Keywords
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