Investigating the Effect of Rosuvastatin, Paracetamol and Co-administration of Rosuvastatin and Paracetamol on Ocular Tissue
Journal Title: Meandros Medical and Dental Journal - Year 2020, Vol 21, Issue 2
Abstract
Objective: Statins and Paracetamol are two drugs that have a high prescription rate all over the world. Possible side effects can easily be augmented because they use the same cytochrome oxidase enzymes in liver. This study aimed to investigate the effect single or combined administration of these drugs on ocular tissues. Materials and Methods: Twenty-eight 12- to 15-month-old rats were divided in four groups: Control, Rosuvastatin (10 mg/kg/day for 7 times a week), Paracetamol (50 mg/kg/day for 5 times a week) and Rosuvastatin (10 mg/kg/day for 7 times a week) + Paracetamol (50 mg/kg/day for 5 times a week) for 8 weeks. At the end of study, intraocular pressure (IOP) was measured and ocular tissues were obtained for histopathological evaluation under anaesthesia with Ketamine and Xylasine (50 mg/kg and 5 mg/kg, respectively). Results: Rosuvastatin showed an IOP dropping effect and paracetamol did not prevent it. Histopathological evaluation mainly revealed retinal nerve fibre layer degeneration. Additionally, different pathological alterations such as corneal oedema and polypoid proliferation were observed in all the treated groups, although they were rare. Conclusion: The IOP dropping effect of rosuvastatin shows that it is safe in glaucoma patients, but this beneficial effect was not observed with Paracetamol. Retinal nerve fibre layer degeneration with both drugs might be one of the reasons for visual disturbances in real life conditions.
Authors and Affiliations
Ayşe İpek Akyüz Ünsal, Fadime Kahyaoğlu, Yavuz Özoran, Alpaslan Gökçimen Buket Demirci
Keywords
Related Articles
- EP ID EP688730
- DOI 10.4274/meandros.galenos.2019.97659
- Views 117
- Downloads 0
Investigation of Potential Genotoxic Effects of Magnetic Field Used in Imaging
Objective: Although the high magnetic field is commonly accepted as harmless for biological tissues, there is no consensus about its biological effects. This study aims to investigate probable genetic damages of magnetic...
Effect of Poly(Methyl Vinyl Ether-comaleic Anhydride) Copolymer on Bond Strength of Experimental Dental Adhesive
Objective: The contents of adhesive systems directly affect their bond strength. The purpose of this in vitro study was to evaluate the bond strength of experimental two-step self-etch (SE) adhesive containing Poly(methy...
Evaluation of the Relationship Between Malocclusion and the Periodontal Health, Caries, Socio-economic Status of Children
Objective: In this study, it was aimed to evaluate the relationship between malocclusions and various factors such as periodontal treatment needs, dental caries, anterior segment crowding and parental socio-economic stat...
Effect of Different Heat-treated Nickel-Titanium Files on Vertical Root Fracture Resistance
Objective: This study aimed to evaluate the fracture resistance of teeth instrumented with rotary files manufactured from different heat-treated nickel-titanium (NiTi) wires. Materials and Methods: One hundred extracted...
Disagreements in the Approach to the N0 Neck and their Causes in Head and Neck Cancers
There are numerous controversial issues in the management of patients with N0 neck. Whether the diagnosis of N0 neck should be made based on the physical examination or imaging methods is contradictory in the first place...