INVESTIGATION OF CARDIAC TROPONIN I CONCENTRATION IN BLOOD SERUM OF A DOMESTIC CAT WITH CARDIOMYOPATHY
Journal Title: Наукові доповіді НУБіП України - Year 2018, Vol 1, Issue 1
Abstract
Cardiomyopathies in a domestic cat can be primary and secondary. The primary cardiomyopathies are genetically determined pathologies of the myocardium. The main methods of heart examination include electrocardiography, radiography and echocardiography. In humane medicine, one of the main methods of diagnosing and obtaining data for monitoring the state of the human heart is to conduct laboratory tests of blood serum to determine such biomarkers as troponin and sodium diuretic peptides. In veterinary medicine in primary hypertrophic cardiomyopathy in a domestic cat, which is considered to be genetically determined, there is a constantly ongoing damage to the myocardium. The purpose of this work is to evaluate the possibility of using a laboratory study of the concentration of cardiac troponin I in the blood serum of a domestic cat for the diagnosis of cardiomyopathies in this species of animals. To study the concentration of cardiac troponin I in the blood serum of a domestic cat, an enzyme immunoassay was used. To diagnose cardiomyopathy in a domestic cat, the method of ultrasound examination of the heart (echocardiography) was used. The results of researches of concentration of cardiac troponin I in serum of clinically healthy patients and patients with cardiomyopathy of cats, mainly of hypertrophic form of cardiomyopathy, are used in this work. The results of our research indicate that the concentration of cardiac troponin I in the serum of patients with cardiomyopathy of cats in comparison with clinically healthy cats is 12.5 times higher (p≤ 0.001). Such results indicate that cardiomyopathy in cats is markedly damaged by the heart muscle. Moreover, damage to the myocardium is characteristic of both hypertrophic and other forms of cardiomyopathy. In the serum of three cats for cardiomyopathy, we found the concentration of troponin I, which had no significant difference, compared with clinically healthy cats and was consistent with the reference data for norm. This may mean that the process of damaging cardiomyocytes in these cats is complete, and a certain etiological factor has led to a remodeling of the heart, which, according to echocardiography, has been diagnosed by us as a hypertrophic form of cardiomyopathy. This form of cardiomyopathy in these animals is considered secondary. Also, the results of a laboratory study of the concentration of cardiac troponin I in the blood serum of cats can help a veterinarian to determine the severity and prognosis of the disease, which can affect the treatment of a domestic cat patient with cardiomyopathy.
Authors and Affiliations
V. N. Plysiuk, M. I. Tsvilikhovski
Keywords
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