Investigation of Ovulation Induction Potential of Siddha Formulation Kalingathi Ennai by Hormone induced Polycystic Ovarian Syndrome in Rats
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 9
Abstract
Polycystic ovary syndrome (PCOS) is the commonest cause (70%) of an ovulatory infertility. The primary abnormality seems to be an excess of androgen production within the ovary that leads to the recruitment of large numbers of small preovulatory follicles, which fail to respond to normal concentrations of follicle stimulating hormone. In recent time’s siddha system of traditional medicine gaining much attention for management of PCOS. Further there is some evidence of positive effects in women with PCOS for towards herbal medicines. It was noted from the siddha literatures that several siddha formulation has potential of preventing the progression of PCOS one such novel drug is Kalingathi Ennai (KE). The main aim of the present study is to evaluate the ovulation induction potential of the formulation KE in hormone induced PCOS in female rats. In the present study PCOS was induced in wistar rats by injecting estradiol and progesterone. Result of the investigation has cleared suggested that treatment with KE at the dose of 100 and 200 mg/kg has significantly increased the level of reproductive hormones such as luteinizing hormone (LH) and follicle stimulating hormone (FSH). Further it was also noted that the level of estrodial and progesterone has shown marked decrease in treatment group when compare to that of the hormone alone induced group. Similar results were observed in rates treated with standard drug clomiphene at the dose of 10mg/kg. It was concluded from the data’s of the present study the ovulation induction potential of the siddha formulation KE may be due to some of the bioactive components present in it. Further investigation at clinical level need to be carried out to justify the present pre-clinical data before exploring the KE for the treatment of PCOS.
Authors and Affiliations
S. Brunda*1 , S. Arulpriya2 , N. Anbu3 , K. Kanakavalli4
Keywords
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- EP ID EP551663
- DOI 10.22192/ijcrms.2018.04.09.001
- Views 153
- Downloads 0
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