Investigation of the effects of different physicochemical parameters on in vitro release kinetics of theophylline from Eudragit NE 30 and Eudragit RS 30D matrix tablets
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 4
Abstract
The present study was considered out to investigate the effects of various physicochemical factors such as compression force, pH of dissolution medium, amount of HPMC (hydroxyl propyl methyl cellulose) on Eudragit NE 30D and Eudragit RS 30D based matrix tablet of Theophylline. Here tablets were prepared using hydraulic press at different compression pressure and using varying concentration of HPMC. In vitro dissolution the studies were carried out using a USP dissolution tester at different pH to observe the effects of pH on release from matrix tablets. The study showed that the compression pressure (2, 3, 4, 5, 6 and 8 tons) had a significant influence on the release behavior of the matrix disks and the release rate was found to be higher with decreased compression pressure. It was found that the release rate markedly increased with the addition of HPMC in the matrices. The effect of pH on drug release is insignificant when Eudragit NE 30D and RS 30D based theophylline matrix tablet was prepared. Theophylline matrix tablet can be successfully prepared using Eudragit NE 30D and Eudragit RS 30D. Optimum Compression pressure should be used for drug release retardation. Using a judicious amount of HPMC with Eudragit NE 30D and RS 30D sustained release matrix tablet can be prepared.
Authors and Affiliations
Mohammad Borhan Uddi , Jakir Ahmed Chowdhury , Kazi Rashidul Azam , M. Kaisarul Islam
Keywords
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