Is low serum iron level a risk factor for gall bladder stone disease?

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Is low serum iron level a risk factor for gall bladder stone disease?

Journal Title: Medpulse International Journal of Surgery - Year 2018, Vol 8, Issue 2

Abstract

Background: Gallstone disease is a common clinical entity affecting the adult population of both sexes. The earliest known gallstones date back to the 21st Egyptian dynasty discovered in the mummy of a priestess of Amenen (1085–945 BC). Gallstones are classified into either pure cholesterol stones, black or brown pigmented stones, or mixed stones. Conditions that favor the formation of cholesterol gallstones are super saturation of bile with cholesterol, kinetically favourable nucleation and presence of cholesterol crystals in the gall bladder long enough to agglomerate into stone. Recent studies have defined the role of trace elements (Fe, Ca, Zn and Cu) and defective pH in the formation of gallstones. If we can predict which factors contribute to the development of gall stone disease, then its prevention could be affected by modifying these factors. This study was planned to study the correlation between serum iron in patients suffering from gallstone disease. Materials and Methods: The prospective study was conducted over a period of 8 months from May 2017 to December 2017 in the Department of General Surgery, Yenepoya Medical College, Mangalore. This prospective study included 50 consecutive patients with imaging studies suggestive of cholelithiasis. Inclusion criteria: All patients above 18 years of age suffering from cholelithiasis confirmed by ultrasonography were included in this study. Exclusion criteria: Patients who have not given consent for blood investigation to estimate serum iron level. Result: 50 patients were included in the study. 40 % of our patients were males and 60% females. There were totally 20 male patients diagnosed with cholelithiasis.10 were found to be anaemic among them.30 patients out of 50 were females and 22 patients among them were anaemic. Serum iron level was low in 16% of the males and 44% of the females. 4 patients with anaemia (8%) and 2 non-anaemic patients (4%) with gallstones have less than normal serum cholesterol levels.22 anaemic patients (44%) and 16 non-anaemic patients (32%) with gallstones have normal serum cholesterol levels. Also 6 patients with anaemia had serum cholesterol levels more than the normal value. There is no effect of anemia on serum cholesterol. Conclusions: There were no significant variations in the serum cholesterol contents of both anemic and non-anemicgroups. Also, there was no significant variation of the above parameter in the male and female patients. The low serum iron level, in one or the other way was leading to formation of gallstones. Key Word: Serum Iron Level, Gall Bladder Stone Disease

Authors and Affiliations

Harshavardhan M N, Vijeth Rai, Harishchandra B

Keywords

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EP ID EP471964
DOI 10.26611/106827
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