Is Ozone (O3) Treatment Effective in Atrophic Rhinitis? Experimental Animal Study
Journal Title: Otolaryngologia Polska - Year 2018, Vol 72, Issue 5
Abstract
Introduction: Atrophic rhinitis (AR) is a disease characterized by atrophy of the mucosa, submucosa, bone tissue due to an unknown cause and excessive nasal cavity enlargement. The disease still has no complete treatment, and the treatment of the functional loss of atrophic cells in AR is still a matter to be investigated. Ozone (O3) therapy has been shown to enhance cell metabolism, angiogenesis, fibroblast activity, and collagen synthesis. Aim: To determine whether ozone treatment affects the disease histopathologically, in experimentally created AR. Material - Method: Twelve Wistar Hanover strain albino male rats were included in the study. Atrophic rhinitis was induced in animals by administering Pasteurella multocida toxin diluted with saline for 21 days to both nasal cavities. A total of 12 animals included in the study were divided into 2 groups as control and study. Ozone gas (60 μg/mL) was administered rectally to the study group for 21 days. After 2 weeks, the rats were decapitated, the nasal cavities were removed as a block, and atrophic rhinitis parameters (epithelial hyperplasia, goblet cell loss, cilia loss, inflammatory infiltration, and vascular ectasia) were evaluated under light microscopy by histopathological examination and statistically interpreted. Result: The incidence of vascular ectasia was significantly lower in the ozone group compared to the control group (p<0.05). There was no significant difference between the groups regarding other histopathologic findings. Conclusion: Ozone treatment was moderate at the histopathological level. We concluded that ozone therapy has no or very limited effect on atrophic rhinitis.<br/><br/>
Authors and Affiliations
Bengül Altaş, Hasan Emre Koçak, Serdar Altınay, Kadir Yücebaş, Ümit Taşkın, Mehmet Faruk Oktay
Keywords
Related Articles
- EP ID EP346831
- DOI 10.5604/01.3001.0012.1265
- Views 70
- Downloads 0
Major salivary gland disorders in children and adolescents
SUMMARY The aim of this study was a review of 67 children treated for salivary gland tumors in the ENT Department Medical University of Gdańsk since 1974 to 2008. In that group we observed 52 children with tumor of the p...
Postoperative vertigo caused by too long stapes prosthesis — radiological diagnostics
The aim of the study was to describe the value of High Resolution Computed Tomography (HRCT) with MPR and VR reconstruction of the temporal bone in patients with persistent vertigo after stapedotomy. High Resolution Comp...
The influence of nasal flow aerodynamics on the nasal physiology
The ability of the human nose to warm and humidify the respiratory air is important to maintaining the internal environment of the lungs, since ambient air is conditioned to nearly alveolar conditions (body temperature a...
Chirurgia endoskopowa w leczeniu guza Warthina nosogardła
The evaluation of the effectiveness of electrical stimulation and kinesitherapy in patients with severe tinnitus