[i]Sambucus nigra[/i] (L.) liophylised extract as source of direct compression tablets obtaining
Journal Title: Ovidius University Annals of Chemistry - Analele Universităţii "Ovidius" Constanţa. Seria chimie - Year 2013, Vol 24, Issue 2
Abstract
The aim of this paper is the valorization of a 10 % anthocyanins elderberries lyophilized extract standardized as cyanidin-3-glucoside in lozenges obtained by direct compression and quality lozenges evaluation according to Romanian and European pharmacopoeia tests. The resulting lozenges with a 600 mg concentration of a 10 % anthocyanins elderberries lyophilized extract standardized as cyanidin-3-glucoside were evaluated using the following tests: appearance and mass uniformity (20 lozenges) disintegration time (6 lozenges), hardness (10 lozenges), anthocyanins assay expressed as cyanidin-3-glucoside using a spectrometric method at pH differential values. The results are expressed as means± standard deviation. The tablets for the two formulas have the same appearance (flat, round, colored in purple – red, non gritty), the dimensional characteristics (height, thickness) are different, average mass complies the pharmacopoeia standards. The lozenges from formula 2 have a higher resistance (215.7 N) and a lower disintegration time (11 min.) according to the official recommended values, due to differences from carbopol polymers differences in properties at the same concentration used in the two formulas. Using the direct compressible products described in this study, the direct compression technique can be easily applied for the manufacture of lozenges, thus ensuring their stability by avoiding heat and humidity factors during the manufacturing process. The resulting lozenges from formula 1 respect the quality specifications provided by the Romanian Pharmacopoeia Xth edition, the European Pharmacopoeia. The lozenges presented a high mechanical resistance (110 N) and a good disintegration time (15 min.)
Authors and Affiliations
Florentina RONCEA, Radu CAZACINCU, Horatiu MIRESAN, Adrian Cosmin ROSCA, Mihaela BRATU, Antoanela POPESCU
Keywords
Related Articles
- EP ID EP162355
- DOI -
- Views 68
- Downloads 0
Determination of antioxidant and antimicrobial properties of Agaricus bisporus from Romanian markets
The antioxidant action of ethanolic extract from Agaricus bisporus which is available in the supermarkets of Bucharest, Romania, was assessed by determining its reducing power and its radical scavenging activity. The det...
Hydrogenation of 1-octene by Co-Mo/MCM-41 catalysts
The synthesis and characterization of MCM-41 supported Co-Mo catalysts and catalytic hydrogenation of 1-octene to n-octane were discussed. BET specific surface area of MCM-41, calculated from N[sub]2[/sub] adsorption/des...
Inorganic fuels mixtures for automotives propulsion engines
The objective of this study is the evaluation of the opportunity to use an inorganic oxygenated compound as ammonium nitrate or urea, to reduce fossil fuels pollution. Our research takes into account the ammonium nitrate...
Quantification of sugar in different brands of drinks
The levels of invert sugar (glucose/fructose mixture resulting from inversion) were determined in different brands of orange, grapefruit, lemon, apricot and raspberry products. Samples of fresh juice, soft drink, syrup,...
[i]Sambucus nigra[/i] (L.) liophylised extract as source of direct compression tablets obtaining
The aim of this paper is the valorization of a 10 % anthocyanins elderberries lyophilized extract standardized as cyanidin-3-glucoside in lozenges obtained by direct compression and quality lozenges evaluation according...