Justification of an alternative method for determination of toxicity of perfume and beauty products by in vitro method on a short-term suspension cell culture-cattle spermatozoa (literature review)
Journal Title: Український журнал сучасних проблем токсикології - Year 2018, Vol 82, Issue 2
Abstract
Introduction. Based on the literature data and directive documentation, the main reasons for the use of alternative methods for determining the toxic effects of perfume and beauty products are set out. Methods — alternative methods based on toxicity assessment using short-term suspension culture of cells of cattle spermatozoa. The toxicological prognosis of the alternative method according to the results of studies is close to the significance of the toxicological prognosis obtained in the experiment with the use of laboratory animals. Mobility is an integral parameter of the physiological, biochemical and morphological status of the short-term suspension culture of mammal cells cattle spermatozoa. Conclusion. The argument for the implementation of alternative methods for determining the toxic effect of perfume and beauty products (PBPs) is aimed at the humane attitude towards animals, as well as reducing costs and reducing the time spent on the study.
Authors and Affiliations
T. F. Kharchenko, V. M. Levitskaya, O. A. Kharchenko, G. V. Golovaschenko, S. O. Khomak, S. S. Isaeva
Keywords
Related Articles
- EP ID EP521487
- DOI -
- Views 111
- Downloads 0
До 75-річчя від дня народження В. І. Медведєва
21 вересня 2017 року виповнилося 75 років від дня народження знаного науковця у галузі гігієни застосування пестицидів і полімерів, а також з проблем діоксинів та біфенілів відділу «Інститут екогігієни і токсикології пес...
Evolution of nutrition system of the population of independent Ukraine
The analysis of nutrition of the population of Ukraine for the period from 1990 to 2017 is presented, as well as the nutritional composition of the minimal set of food products (food consumer basket) for persons belongin...
Changes in integral indicators of the functional state of experimental animals with the long-term introduction of cadmium chloride and nanoparticles of sulfide cadmium of different sizes
The purpose of the study was a comparative assessment of the integral indicators of the functional state of experimental animals under conditions of prolonged exposure to cadmium chloride and nanoparticles (NP) of cadmiu...
Evaluation of the risk of oral administration of residual amounts of insecticides after disinsection of food grain reserve
Introduction. Treatment of grain reserves (GR) with insecticides at the beginning of storage is a common technology for combating insect pests. In Ukraine, deltamethrin (synthetic pyrethroid), pirimiphos-methyl and chlor...
Toxicological and hygienic assessment and regulation of the use of herbicides based on imidazolinone derivatives on sunflowers
Imazamox and imazapyr are a widely use herbicides for the control of wide range of weeds in agriculture. Imazamox and imazapyr containing formulations are recommended and used for sunflower protection. For the purposes o...