Justification of antibacterial therapy for atopic dermatitis
Journal Title: Український журнал дерматології, венерології, косметології - Year 2019, Vol 0, Issue 3
Abstract
Skin is the largest organ of the human body, colonized by millions of microorganisms, most of which are harmless and even beneficial to their host. Congenital and acquired skin immunity can adapt to the skin’s microbiota, but the microbiota also affects the immune system. The skin microbiota consists of two groups: on the one hand, it is a stable composition of microorganisms, and on the other — representatives of the external environment that are present on the skin for a certain period of time before their disappearance. From a bacteriological point of view, the skin is considered as a culture medium. The composition of the skin microbiota depends on heredity, diet, lifestyle, region of residence. In addition, anti-inflammatory topical therapy for atopic dermatitis and psoriasis is of some importance. Frequent hand washing causes a break in the skin’s barrier function, which causes inflammation and changes in the microbiome of hand skin. The diversity of skin microbiota in lesions in atopic dermatitis is also significantly reduced compared to healthy individuals. Impaired regulation of the immune response of the skin is evident in some skin diseases, such as psoriasis, atopic dermatitis. In cases of concomitant infection and chronic disease, an antimicrobial approach to therapy may be used. The effectiveness of treatment correlates with a decrease in the relative amount of S. aureus. From the clinical experience, it is known that exacerbation of atopic dermatitis, which is more related to the restructuring of the microbiota, requires periodic inclusion of antimicrobial agents into the algorithm of treatment. We observed 18 patients with atopic dermatitis aged from 18 years. Patients were diagnosed with atopic dermatitis complicated by superficial streptoderma. Treatment with Betaderm® was used for 7—10 days which had a clear therapeutic effect. The therapy was performed according to the latest European protocol for the treatment of atopic dermatitis.
Authors and Affiliations
L. D. Kaliuzhna, A. V. Petrenko
Keywords
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- EP ID EP672106
- DOI 10.30978/UJDVK2019-3-83
- Views 71
- Downloads 0
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