Kalanchoe pinnata aqueous extract safety and potential cardioprotective effects in isoprenaline treated rats
Journal Title: UNKNOWN - Year 2018, Vol 7, Issue 5
Abstract
Introduction: Kalanchoe pinnata (Crassulaceae) aqueous extract antihypertensive property has been proven. This study aimed to evaluate the safety and potential cardioprotective effects of the extract in isoproterenol treated rat. Methods: A total of 35 adult wistar rats were randomly and evenly distributed into groups 1-7 then treated for 28days. Control groups 1-3 received 10mL/kg water (per os, neutral), 150mg/kg isoproterenol (ISO, sc, 48 and 24hours prior to sacrifice, negative) and ISO plus 10mg/kg propranolol (per os, ten days prior to sacrifice, positive). Safety test groups (4-6) received K. pinnata extract (50, 100 and 200mg/kg per os). Cardioprotective test group 7 received K. pinnata (100mg/kg per os) and ISO. The sacrifice of rats was carried out on day 29 and blood collected for haematological and biochemical analyses. Liver, kidney and heart were collected weighed and preserved for histopathological analysis. Results: There was no observable sign of toxicity. No significant difference was observed between the relative weight of the heart from groups 1-7. The platelet value dropped from 794.7x10/L (group 2) to 284x10/L (group 7, p<0.05). An elevated value of creatine Kinase-MB (20.64U/L) was obtained in group 2, which decreased in other groups (P<0.05). In group 7, however, the extract (100mg/kg/day) reduced (P>0.05) the level of CK-MB compared to group 2. The level of triglycerides was elevated in group 2, 4 and 6 compared to group 1. Histopathological analysis of the heart showed the safety of the extract. Conclusion: We demonstrated that K. pinnata extract (100-200mg/kg/day, per os) might be cardioprotective.
Authors and Affiliations
Orelien Sylvain Mtopi Bopda, Nathalie Nadège Chendjou Koumtouzi, Danielle Bilanda, Désiré Paul Djomeni Dzeufiet, Christian Tiambo Keambou, Théophile Dimo
Keywords
Related Articles
- EP ID EP589797
- DOI -
- Views 99
- Downloads 0
Therapeutic activity of Thonningia sanguinea aqueous extract, Vahl on an experimental colibacillosis in chicken
Broiler breeding is faced with serious diseases, including colibacillosis, which is the leading cause of antibiotic therapy and the second leading cause of mortality in poultry after salmonellosis. It is caused by avian...
Comparison of inhibitory effect of ibuprofen with Piper guineense Schumach and Thonn. on some reproductive hormones in female rats
The aim of the present study was to compare the inhibitory effect of ibuprofen with oral administration of Piper guineense leaf extract on follicle-stimulating hormone, luteinizing hormone, progesterone and estrogen in f...
Gastro-duodenal protective effect of aqueous leaf extract of Daucuscarota sativus Linn. (Apiaceae) in rats and its possible mechanism of action
Background: Daucuscarota sativus L. (Apiaceae) commonly known as ‘carrot’ is a multipurpose herb cultivated in different parts of the world for its edible roots, juice, oils and leaves. Carrot root as well as its leaves...
Comparative analysis of total tannins in Plectranthus barbatus Andrews water, acetone and methanolic extracts in Kenya
The purpose of this study was to identify the most suitable solvent for use in extracting tannins from Plectranthus barbatus Andrews leaves, a plant indigenous to various parts of Kenya. The plant was traditionally used...
In-vitro evaluation of Scoparia dulcis Linn. for anti –urolithiatic activity
Introduction: Urolithiasis is a complex process that occurs from series of several physicochemical event including super-saturation, nucleation, growth, aggregation and retention within the kidneys. Data from in-vitro, i...