KINETIC MODELING OF RASAGILINE MESYLATE FROM NANOSCALE SOLID LIPID PARTICLES
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 11
Abstract
Objective: The present study is aimed to investigate the In-vitro release behavior of the Rasagiline mesylate loaded nanoscale solid lipid particles to provide the quality based controlled release system. Methods: The Rasagiline mesylate loaded Nanoscale particles prepared using the microemulsion technique with biodegradable and biocompatible lipid (stearic acid), surfactant (polyethylene-polypropylene glycol) and co-surfactant (polyoxyethylene20 sorbitanmonooleate). The prepared nanoscale solid lipid particles, particle size distribution, polydispersity index, zeta potential, entrapment efficiency, drug loading and drug content were characterized. The fabricated particles surface morphology was examined by transmission electron microscope. In-vitro release of Rasagiline mesylate loaded nanoscale solid lipid particles was studied using conical flask method. Release kinetics of Rasagiline mesylate from nanoscale solid lipid particles were studied using mathematical models.Results: The resulting Rasagiline mesylate loaded nanoscale solid lipid particles were successfully prepared with optimum particle size distribution, polydispersity index, zeta potential, entrapment efficiency, drug loading and drug content. Statistically significant differences were found among the drug release profile from RMSLN-I and RMSLN-II. Applying kinetic mathematical models, the mechanism of Rasagiline mesylate loaded nanoscale solid lipid particles release from the two formulations were found to be followed higuchi model, as the plots showed high linearity, with a correlation coefficient (R2) value of 0.98 or more. The ‘n’ value of korsmeyer-Peppas model lies below 0.5 and the mechanism controlling the drug release was Fickian diffusion.Conclusion: The prepared Rasagiline mesylate loaded nanoscale solid lipid particles controlling the drug delivery through diffusion dominated mechanism.Â
Authors and Affiliations
Viveksarathi Kunasekaran, Kannan Krishnamoorthy
Keywords
Related Articles
- EP ID EP578176
- DOI -
- Views 52
- Downloads 0
FORMULATION DEVELOPMENT AND EVALUATION OF ORALLY DISINTEGRATING TABLET OF CHLORPHENERAMINE MALEATE BY SUBLIMATION TECHNIQUE
Objective: Chlorpheneramine maleate is a first-generation antihistamine drug used in the treatment of allergic conditions like rhinitis, urticaria, and cough cold, etc. In present work, the challenge has been made to dev...
ROLE OF NITRIC OXIDE (NO) IN CAPSAICIN MEDIATED ANTI-PLATELET ACTIVITY IN IN VITRO, IN VIVO, EX-VIVO MODEL OF PLATELET AGGREGATION ASSAY AND ARTERIAL THROMBOSIS IN RAT: POTENTIAL THERAPEUTIC TARGET?
Objective: Although recent advances in the treatment of congestive heart disease, mortality among patients’ remains a questionable remark. Therefore, we evaluated the role of capsaicin on in vitro and ex vivo platelet...
CURRENT STATUS OF MATERIOVIGILANCE GLOBALLY-AN UTTER OVERVIEW WITH CLINICAL CASE PERUSAL
Today’s medical devices are the lifesaving tool and these tools are very frequently used globally since long ago. With the increase in the number of medical devices and their uses, there is an increase in the number of a...
PHARMACOLOGICAL EVALUATION OF ANTI-INFLAMMATORY, ANALGESIC AND ANTIPYRETIC EFFECTS OF GYNOCARDIA ODORATA ROXB IN ANIMAL MODELS
Objective: The purpose of this investigation was to study the anti-inflammatory, analgesic, and antipyretic properties of methanol extract of Gynocardia odorata roxb (MEGO) in rats and mice.Methods: The plant material wa...
ANTIULCER ACTIVITY OF THE MOST ACTIVE SUB-FRACTION OF METHANOLIC LEAF EXTRACT OF BUCHANANIA LANZAN SPRENG
Objective: To evaluate the antiulcer activity of the most active sub-fraction of Buchanania lanzan Spreng. leaves methanolic extract (BLE).Methods: The antioxidant activity of BLE fractions and sub-fractions has been ass...