Kronik Granülomatöz Hastalarında ve Bu Hastalığı Genetik Olarak Taşıyan Bireylerde Lenfosit Fonksiyonları
Journal Title: Turkish Journal of Immunology - Year 2019, Vol 7, Issue 2
Abstract
Introduction: Chronic granulomatous disease (CGD) is classically known as phagocytic system disease. However, in recent years, the observation of the development of autoimmunity, colitis-like findings during follow-up has suggested that the acquired immune system may also be defective. The aim of this project is to investigate the percent of T and B lymphocytes, and function of T lymphocytes in patients with CGD and carriers. Material and Methods: Eleven patients followed for CGD (3 X-CGD, 8 OR-CGD) in our clinic and 6 carrier mothers of OR-CGD were included into the study. The percentages of lymphocytes and their subtypes, lymphocyte proliferation, regulator T cell (Treg), intracellular cytokine content of patients with CDG and carriers were determined in comparison to healthy controls. Results: There was no statistically significant difference in percentages of T cell, B cell and NK cell and subtypes of T and B cells in the mothers of patients compared to age matched healthy controls. The percentage of naïve B cells was significantly higher in the patients with CGD compared to those of healthy subjects (p<0.001). There were no significant differences in lymphocyte proliferation, Treg cell percentage, intracellularIL-17 levels, but IFN-γ levels were significantly increased in both patients with CDG (p=0.030) and carriers (p=0.038) when compared with age-matched healthy controls. Conclusion: Increased naive B cells were found in CGD patients. High levels of IFN-γ in patients and carriers need to be further evaluated by further studies. In addition, the normal percentages of Treg and IL-21 in the carriers as in healthy subjects may be offered as the protective mechanism for autoimmunity.
Authors and Affiliations
İsmail ÖĞÜLÜR, Ezgi BARIŞ, Ayça KIYKIM, Dilek BAŞER, Gamze AKGÜN, Ahmet ÖZEN, Safa BARIŞ, Elif KARAKOÇ-AYDINER
Keywords
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- EP ID EP670733
- DOI 10.25002/tji.2019.1111
- Views 112
- Downloads 0
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