Langerhans Cell Histiocytosis – A Review and Case Report
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2018, Vol 6, Issue 11
Abstract
Langerhans cell histocytosis (LCH), formerly known as histiocytosis X is a selectively rare disease with an incidence of 2-5 cases per million. It refers to group of conditions characterized by uncontrolled stimulation and proliferation of normal antigen-processing bone marrow derived cell- langerhans cells. Langerhans cells histocytosis mainly affects the skull, vertebrae, ribs, maxilla and mandible in children and the long bones of adults. Symptoms range from none to pain, swelling and tenderness over the site of lesion, gingival enlargement, oral ulcers, and mobility of teeth. This disease presents oral manifestations which can be expression of the systemic condition, hence diagnosing such lesion becomes difficult for oral physicians, and LCH is confirmed by histological, immune histochemical staining. These lesions are commonly seen in childhood; we report a case of 15 years old male child, who presented with swelling of gums, mobility of almost all teeth since 6 months. On the basis of histological and immune histochemical features (tumor cells are positive for CD 1a and S100 protein); a diagnosis of langerhans cell histocytosis was made.
Authors and Affiliations
Parul Chhabra, Pujit Chhabra, Saanvi Sihag, Mohit Kumar, Sushila Kumari
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