Leiomyosarcoma of Superior Vena Cava and Inferior Vena Cava - Two Rare Case Reports
Journal Title: International Journal of Current Research and Review - Year 2018, Vol 10, Issue 15
Abstract
Objective: This article attempts to describe two cases of vascular leiomyosarcoma, one arising from the superior vena cava in a 22 year old male patient, and the other arising from the inferior vena cava in a 53 year old female. The objective was to investigate and diagnose the two cases. Material and Methods: Imaging studies (CT scan) were done in both the cases subsequent to initial clinical examination. After surgical resection, the specimens of the tumors were sent to the Pathology Department for histopathological examination. The sections were stained using Haematoxylin and Eosin (H & E). Immunohistochemistry (IHC) was also done. Results: On gross examination, the first case showed a segment of a large vessel with a mass attached to the inner wall and protruding outside through the lumen. Tumor on cut section was solid, firm, homogenous grayish white with focal necrotic areas. In the second case, the vessel wall with an attached firm to hard lesion was received. On histological examination, both the cases were diagnosed to be malignant spindle cell tumor. Immunohistochemical staining revealed that the tumor cells were diffusely positive for SMA and Desmin and negative for S100 and CK. The two cases were reported as vascular leiomyosarcoma, one of the Superior vena cava and the other case of Inferior vena cava. Conclusion: Vascular leiomyosarcoma is a very rare tumor and the Inferior vena cava is the most common site (50%). The Superior vena cava (SVC) is exceptionally involved and only a dozen cases have been previously reported. An accurate imaging and histopathological diagnosis is essential as they can affect the prognosis and treatment approach. So such cases should be thoroughly examined and followed.
Authors and Affiliations
Dr. Puja Khanna
Stem Cells and Metallothionein - A Review
Stem Cells are capable of self renewal and can differentiate into other lineages upon induction with specific growth factors and proteins. Mesenchymal stem cells obtained from various sources like adipose tissue, umbilic...
Formation of the Median Nerve by an Additional Lateral Root: Embryological Basis and its Clinical Implications
Aim: A complicated network of arrangement of brachial plexus lead to frequent variations in this region. Therefore, a careful dissection of cadavers was performed during routine dissection classes of first year MBBS stud...
Attitude and Practices of early adults of Lucknow city about Heart diseases: A cross-sectional survey
Introduction: CVD is a leading cause of mortality in India of which majority of individuals are adults in the age group of 20-40 years. However because of less knowledge among people evident from various researches the a...
Growth and Characterization of NaCl doped Organometallic L-Asparagine Cadmium Chloride Monohydrate (LACCM) Crystals
Single crystals of sodium chloride (NaCl) doped organometallic nonlinear optical material L-asparagine cadmium chloride monohydrate (LACCM) were successfully grown by slow evaporation method at room temperature. Grown cr...
A Comparative Study of Isolation of Obligate Anaerobes and Facultative Anaerobes in Microbial Flora of Non- Vital Teeth in Diabetic (Type II) and Non-Diabetic Patients
Introduction: The aim of the study was to evaluate and compare the anaerobic microflora (obligate and facultative) of the root canals of non vital teeth with periapical lesions, in diabetic (Type II) and non-diabetic pat...