Levels of folic acid, vitamin B12 and Malondialdehyde in stroke patients
Journal Title: Medpulse International Journal of Biochemistry - Year 2017, Vol 3, Issue 1
Abstract
Background: Stroke is a major health problem in elderly population, however there remains a significant subset of younger patients with ischemic stroke in whom conventional vascular risk factors play a smaller role. Folic acid and vitamin B12 deficiency may cause incr atherosclerosis of cerebral arteries at young age. Oxidative stress characterized by increased generation of oxygen free radicals results in generation of lipid peroxidation product like acute ischemic stroke. Aims and Objectives: MDA in patients of stroke in young with age and sex matched controls. Government Medical College, Aurangabad. we studied 50 cases of stroke in young who were free from conventional vascular risk factors like diabetes mellitus, hypertension, hypercholesterolemia and cigarette smoking with 5 sex matched controls were selected. Their fasting serum folic acid, vitamin B12 levels by chemiluminescence method and serum Malondialdehyde level by Thiobarbituric acid method were determined. serum folic acid and vitamin B12 was significantly decreased in patients of stroke in young compared to controls with p value of <0.0307 and <0.0232 respectively. The serum MDA levels was very highly significant [p<0.001] in patients of stroke in young than in controls. deficiency play as an important independent risk factor for stroke in young patients in factor. The serum MDA was significantly raised
Authors and Affiliations
Kamalakar Mane, Shilpa Asegaonkar, Arvind Gaikwad, Mahendra Kamble
Keywords
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