Study on correlation between high density lipoprotein and cardiac markers in patients of type II diabetes mellitus complicated with hypertension
Journal Title: Medpulse International Journal of Biochemistry - Year 2017, Vol 5, Issue 1
Abstract
Problem statement: Diabetes mellitus is characterized by loss of the insulin-producing beta cells of the isolates of Langerhans is the pancreas, leading to insulin deficiency. In the early stage of type 2, the predominant abnormality is reduced insulin sensitivity. At this stage, hyperglycemia can be reversed by a variety of measures and medications that improve insulin sensitivity or reduce glucose production by the liver. Plasma homocysteine is considered to be a maker of endothelial dysfunction and suggested to be a causative factor for atherosclerosis and arterial stiffness. It is clear that hyperhomocysteinemia can promote atherosclerosis. Methods: A prospective short study was undertaken to find out the correlation between high density lipoprotein and cardiac markers in various age groups, this study was carried out randomly in 100 patients having Type-II Diabetic Mellitus complicated with hypertension who was attending the OPD in the department of Medicine in MGM Medical College & L.S.K. Hospital, Kishanganj. The duration of the study was, from June2015 to October 2016. The data collection was carried out after selection of sampling unit according to the inclusion and exclusion criteria. The biochemical test parameters were measured using appropriate and standard with standard operating protocol in the clinical biochemistry laboratory of the institute. The SPSS statistical package was used for analysis. ± standard deviation was recorded. P value <0.05 was considered significant. Results: The age of 100 cases enrolled in this study ranged between 17 to 76 years. The 2% of cases was of age group of <20 yrs., 18% were between 21 to 40 yrs, 55% were between 41 to 60 yrs. and 25% were >60 yrs. of age group. The majority of cases 62% were male and 38% were female. Suggesting that the type-II complicated with pretension is more common in males than the females. Out of 100 cases studied 22 patients were having abnormal homocysteine and HDL. Most of the patients with abnormal homocysteine and HDL is having positive CRP (19 out of 22 that means approximately 79%) however only 21% (3 cases out of 22) were having negative CRP. The 19 cases out of 22 having positive CRP, abnormal homocysteine and HDL, 15 were male and 4 were female. Out of these 19 cases having positive CRP abnormal homocysteine and HDL. One patient was of age group between 0-20 yrs., 4 were age group between 20-40 yrs., 8 were of age between 41 to 60 yrs. and remaining 6 were of >60 yrs. of age. Out of 3 cases having negative CRP with abnormal homocysteine and HDL, 2 were and 1 was female. The 2 cases of it was of age group between 41 to 60 yrs., 1 was of >60 yrs. of age. Conclusion: No significant correlation has been found between homocysteine level and CRP. There was significant correlation with HDL levels and CRP.
Authors and Affiliations
Kavita Jaiswal, Niru Chhetri
Keywords
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