Lifestyle-related diseases in Okinawa school children -Dyslipidemia, Obesity and metabolic syndrome-
Journal Title: Journal of Analytical Bio-Science - Year 2011, Vol 34, Issue 5
Abstract
Cardiovascular disease (CVD) risk factors are associated with weight status and/or insulin resistance. However, these associations are not fully understood in schoolchildren. In the present study, we investigated the relationship between CVD risk factors and weight status, and the effect of insulin resistance (IR) on these associations in schoolchildren who underwent screening for lifestyle-related disease in Okinawa. Body mass index z-score (BMIz) was employed as an index of weight status. Children with Ⅱb and Ⅳ hyperlipidemia had significantly higher IR than those with normolipidemia and Ⅱa, even after correcting for BMIz. BMIz were linearly associated with relative risks having adverse levels of all factors, except for glucose and low-density lipoprotein cholesterol (LDL-C) in boys, and excluding glucose, LDL-C and adiponectin in girls. These associations were weakened after adjustment for IR, but still significant in cases of blood pressure, uric acid and CRP in boys and diastolic blood pressure, high-density lipoprotein cholesterol, uric acid and CRP in girls. To prevent future development of CVD, it might be quite important for schoolchildren to maintain BMIz within the normal range.
Authors and Affiliations
Takao Ohta
Keywords
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