Clinical state of acute myocardial infarction with increased phosphoglucomutase activity: The relationship between phosphoglucomutase activity and acute thrombosis
Journal Title: Journal of Analytical Bio-Science - Year 2012, Vol 35, Issue 2
Abstract
Phosphoglucomutase (PGM) is a key enzyme in cellular glucose utilization and energy homeostasis. We previously found that patients with acute myocardial infarction (AMI) showed high PGM activity, especially those with ST-elevation myocardial infarction (STEMI). For clarifying whether PGM activity was related to acute thrombosis in patients with STEMI, the PGM activity in both a rat acute thrombosis model and in patients with AMI was evaluated. In the rat thrombosis model, PGM activity increased irrespective of the development of thrombosis, whereas PGM activity increased in AMI patients with coronary thrombosis, especially those in a shock state. Our findings suggest that PGM activity can increase with myocardial damage, the formation of a thrombus, and the presence of inflammation associated with coronary plaque rupture. PGM activity might be useful for the diagnosis of acute coronary thrombosis in AMI patients and a useful predictive marker in the prognosis of AMI patients.
Authors and Affiliations
Makoto Nishinari
Keywords
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