Liver enzymes in obstructive sleep apnoea syndrome
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2017, Vol 7, Issue 8
Abstract
Background: Obstructive sleep apnea syndrome (OSAS) is a common form of sleep disordered breathing. OSAS is associated with the cluster of metabolic abbreations that comprise the metabolic syndrome, including nonalcoholic fatty liver disease. Aims and Objectives: We investigated the effects of OSAS and its treatment with short term nasal continuous positive airway pressure (CPAP) therapy on serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. Materials and Methods: We studied 20 adult males and postmenopausal female aged 50-60 years with OSAS. None had hepatitis B antigen or C antibody positive, autoimmune disease, an alcohol intake higher than 20 g/day or on regular use of hepatotoxic drugs. Abdominal ultrasound was done to establish the presence of fatty liver. Serum levels of AST and ALT were determined at baseline and after nasal CPAP treatment. Results: The baseline ALT and AST values were within normal limits. There was no significant change in ALT (25.9 ± 4.7 vs. 26.2 ± 3.4 after CPAP, P > 0.05) and AST (27.5 ± 2.0 vs. 24.6 ± 1.8, P > 0.05) values after one night of CPAP treatment. Conclusion: Serum aminotransferase may have limited use in assessing liver damage in the OSAS patients. Short term CPAP therapy doesn’t seem have beneficial effects on serum aminotransferase levels in patients of OSAS.
Authors and Affiliations
Kanimozhi Sadasivam, Kuldeep Patial, Krishnan Ravi, Saravanan Aiyyavo
Keywords
Related Articles
- EP ID EP290623
- DOI 10.5455/njppp.2017.7.0414006052017
- Views 102
- Downloads 0
Natural menopausal age: Correlation with body mass index and various reproductive factors in postmenopausal women
Background: Natural menopause can be defined as cessation of menstruation in which women have experienced 12 consecutive months of amenorrhea that results from loss of ovarian follicular activity. Usually, women attain m...
Evaluation of association between psychological stress level during menopausal transition period and serum estrogen level among middle-aged women: A cross-sectional study
Background: Menopause is a gradual transition from reproductive to non-reproductive phase in women during which there is substantial fluctuation in estrogen or estrogen deficiency. Furthermore, women encounter various ps...
Effect of prescription waiting time on patient satisfaction mediated by service quality of pharmacy unit in public hospital in Bandung city
Background: The Indonesia National Health Insurance (NHI) is one of the social protections to ensure all people to health. Improving the quality of good service is a demand for pharmacy unit to improve the services quali...
A mathematical approach in the management of hydrocephalus from tuberculous meningitis
Background: The unavailability of standardized treatment algorithms to properly select tuberculous meningitis (TBM) patients for surgery delays optimal management. Aim and Objective: This study developed a mathematical m...