Liver Function In Pediatric β-Thalassemia Major Patients Receiving Multiple Blood Transfusions
Journal Title: IJAR-Indian Journal of Applied Research - Year 2015, Vol 5, Issue 9
Abstract
Background- Beta –thalassemia major is an autosomal recessive disease that leads to severe hemolytic anemia in early infancy. Repetitive blood transfusion leads to iron overload which adversely affect the function of liver, heart and endocrine glands. Objective-The aim of the present study was to investigate the impairment in liver function with the increased iron over - load in pediatric patients of β- thalassemia major. Methods-The analyzed group consisted 50 subjects and 50 controls further divided in two age groups i.e. I and II. Fer - ritin was measured by ferrozine method. Results-Thalassemic subjects have significantly higher ferritin, AST,ALT and bilirubin level. Albumin level was found to be significantly reduced showing impaired liver function. Conclusions- Repetitive blood transfusions leads to iron overload in thalassemic children causing significant damage to liver resulting in elevated level of ferritin, AST, ALT and bilirubin and reduced synthetic capacity of albumin.
Authors and Affiliations
Madhu choudhary, Dr. V. D. Bohra
Keywords
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