LOGIC REGRESSION FOR DIAGNOSTIC CLASSIFICATION BY MEANS OF BIOMARKER PANELS
Journal Title: Colloquium Biometricum; Colloquium Biometricum (Online) - Year 2016, Vol 46, Issue
Abstract
Biomarkers can indicate a variety of health or disease characteristics, including the level or type of exposure to an environmental factor, genetic susceptibility, genetic responses to exposures, markers of subclinical or clinical disease, or indicators of response to therapy. In this paper we presented using the logic regression for diagnostic classification by means of biomarker panels. The sample collective comprised 389 highly characterized rheumatoid artritis patients and 390 controls, composed of 200 healthy and 190 osteoarthritis samples. The predictive panel consisted of the most promising 11 biomarkers for the early diagnosis of rheumatoid artritis, collected in serum. Obtained results show that the Logic II is the simplest model and performs well, resulting in the lowest misclassification error rate on the test set.
Authors and Affiliations
Jan Bocianowski, Kamila Nowosad
Keywords
Related Articles
- EP ID EP190145
- DOI -
- Views 104
- Downloads 0
LOGIC REGRESSION FOR DIAGNOSTIC CLASSIFICATION BY MEANS OF BIOMARKER PANELS
Biomarkers can indicate a variety of health or disease characteristics, including the level or type of exposure to an environmental factor, genetic susceptibility, genetic responses to exposures, markers of subclinical o...
On the efficiency of orthogonal treatment contrasts in multistratum incomplete split-split-plot designs constructed by square lattice designs
We construct an incomplete split-split-plot design for three factor experiments. The method is based on a semi-Kronecker (Khatri-Rao) product of three matrices. We use two square lattice designs for whole plot treatments...
THE EFFECT OF THE ORCHARD HABITAT STRUCTURE AND YEAR ON APPLE CLEARWING MOTH S. MYOPAEFORMIS ABUNDANCE
In years 2008-2010 in orchard habitat near Czempiń in south Wielkopolska a mass appearance of apple clearwing moth Synanthedon myopaeformis and his larval ectoparasitoid Liotryphon crassiseta was stated. There were 7960...
RANDOM FORESTS SUPPLEMENTED BY PARALLEL FENCES PLOTS: A STUDY IN SPIROMETRIC DIAGNOSTICS
We try to assess, what truly can be obtained when using only the spirometric measurements for the diagnosis of pulmonary disorders. Using spirometric data recorded for 202 patients and the Random Forests methodology, we...
A REMARK ON ESTIMATING DEFECTIVENESS IN SAMPLING ACCEPTANCE INSPECTION
Summary The problem of estimating a probability of success in a Binomial model is considered. The classical estimator is compared with the estimator which uses the information about non-homogeneity of the sample. An appl...