LONG-TERM SAFETY AND TOLERABILITY OF FENTANYL CITRATE NASAL SPRAY IN THE TREATMENT OF BREAK THROUGH CANCER PAIN (BTCP) IN SUBJECTS TAKING REGULAR OPIOID THERAPY
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 2
Abstract
An ideal patient-controlled analgesic (PCA) opioid would have rapid onset and longer duration of action when compared to the currently existing opioids including morphine. The purpose of this study was to verify the efficacy and safety in cancer patients experiencing breakthrough cancer pain. Selected patients with Break through Cancer Pain (BTCP) episodes received the fentanyl citrate nasal spray. Pain relief score, pain intensity score and BTCP episodes per day were assessed directly by questionnaires, recorded data and analyzed statistically. Demographic and medical data were showed that only 18.5% of patients suffered from headache, 25.9% of patients suffered from dizziness, 25.9% of patients suffered from nausea and 33.3% of patients suffered from constipation. Fentanyl citrate nasal spray showed quick onset of action within 5 minutes. Fentanyl citrate nasal spray and morphine sulphate tablets were comparable in controlling BTCP episodes. However, fentanyl nasal spray was rated better than morphine sulphate tablets for its quick onset of action and ease of care by patients and nurses.
Authors and Affiliations
Palanisamy P, Yoganand Kumar, Srinath K. R. , Pooja Chowdary
Keywords
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