Magnesaemia in dialysis patients – the unappreciated feature of mineral metabolism
Journal Title: Postępy Nauk Medycznych - Year 2015, Vol 28, Issue 10
Abstract
Magnesium plasma concentration are seldom controlled in dialysis patients. This articleaddresses the role of magnesium as the fourth most abundant cation, the consequencesof hypo- and hypermagnesaemia, and the prevalence of hypo- and hypermagnesaemia inpatients on dialysis. In people with CKD and in dialysed patients, plasma level of magnesiumcould be above normal, because of the lack of excretion by the kidneys, normal orbelow normal, as a result of diminished reabsorption and/or removal of magnesium duringdialysis. In general population the hypomagnesaemia is a significant predictor of increasedcardiovascular morbidity and mortality, and dietary magnesium intake is inverselyassociated with mortality risk. More and more experimental studies report a protectiveeffect of magnesium on cardiovascular system, including inhibitory effects of magnesiumon vascular calcification. Mechanism of this protective magnesium activity is intenselystudied. Recently published data obtained from a large group of dialysed patients correlatedthe higher concentration of magnesium in plasma (including mild hypermagnesaemia)with lower mortality, and lower vascular calcification, which confirmed the earlierobservations made on smaller groups of patients. Thus, it seems necessary to monitor theconcentration of magnesium in dialysed patients, and prevent its deficiency. Though mildhypermagnesaemia appears of no consequences to the dialysis patients’ health, and evencould be protective, the lack of large interventional clinical trials does not allow, at present,to promote magnesium supplementation to increase its level above normal with an intentionto prevent vascular calcification and reduce mortality
Authors and Affiliations
Dorota Daniewska, Katarzyna Chmiel-Majewska, Ryszard Gellert
Keywords
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