Mast Cells in Leprosy Patients with Reversal Reactions
Journal Title: Turkish Journal of Immunology - Year 2017, Vol 5, Issue 1
Abstract
Background: Reversal reaction (RR) is an acute reaction on chronic episode which often contributes to withdrawal of treatment and disability in leprosy patients. Previous study showed that mast cells in reactive tuberculoid lesions biopsy material had lower density than non reactive tuberculoid lesions. Granulomatous lesions in leprosy patients with high mast cells density were more likely to progress into severe reversal reaction. Objective: To examine mast cells level in reversal reaction patients (RR) and non-reactional leprosy patients (non-RR) Methods: Fiftysix leprosy patients consist of 28 with reversal reactions and 28 non-reactional leprosy were assessed for mast cells levels by immunohistochemistry staining. The mast cell numbers in both groups were analyzed using Independent T-test. Results: Mast cells were increased in the reversal group (p<0.05). Conclusion: Mast cells level is associated with reversal reaction of leprosy. Keywords: Leprosy, reversal reaction, mast cell
Authors and Affiliations
Renni Yuniati, FM Fatihatul, A Fika, S Prasetyowati
Keywords
Related Articles
- EP ID EP449797
- DOI 10.25002/tji.2017.542
- Views 107
- Downloads 0
Local Sympathetic System Dysfunction in Patients with Acute Allergic Rhinitis; an Electrophysiological study of Local Sympathetic Skin Responses Test
Introduction: In this study, we aimed to investigate sympathetic nervous system functions by local sympathetic skin responses of the nasal septum in patients with acute allergic rhinitis. Material and Methods: Eighty-fiv...
Kronik Granülomatöz Hastalarında ve Bu Hastalığı Genetik Olarak Taşıyan Bireylerde Lenfosit Fonksiyonları
Introduction: Chronic granulomatous disease (CGD) is classically known as phagocytic system disease. However, in recent years, the observation of the development of autoimmunity, colitis-like findings during follow-up ha...
Identification of Hemagglutinin Protein from Streptococcus pneumoniae Pili as a Vaccine Candidate by Proteomic Analysis
Introduction: Streptococcus pneumoniae is a Gram-positive, bacterial human pathogen that causes a large number of respiratory tract infections, such as pneumonia and sinusitis, as well as invasive diseases such as septic...
Expression of Tumor Necrosis Factor-α and Interleukin-6 in Chronic Suppurative Otitis Media
Introduction: Chronic suppurative otitis media (CSOM) with cholesteatoma is decribed by keratin epithelial invasion in the middle ear and osteolysis in both of the ear bones and the temporal bone. Some inflammatory facto...
The Effect of Lactobacillus reuteri on the Percentage of Th17 Cells and Level of IL-17 in Staphylococcus aureus-Induced Puerperal Infection BALB/c Mice
Background: Puerperal infection is an infection of the reproductive tract during labor or puerperal period, which is largely caused by Staphylococcus aureus infection resulting in Toxic Shock Syndrome (TSS). The prevalen...