Meningeal solitary fibrous tumor: report of a case and literature review
Journal Title: Folia Neuropathologica - Year 2005, Vol 43, Issue 3
Abstract
Solitary fibrous tumor is a rare neoplasm that most often involves the pleura. The increasing numbers of this neoplasm have also been reported to date in extrapleural sites. We report a case of a twenty-four-year-old female with right frontal mass. Histologically, the tumor composed of spindle cell proliferation. Tumor cells were found to be positive for CD34 and CD117 with immunohistochemical studies. Ten months follow-up was uneventful. Seventy seven cases of meningeal solitary fibrous tumor from the literature are analysed and pathological, immunohistochemical and clinical features are discussed. Solitary fibrous tumor has a slight female predominance, with a male to female ratio of 1:1.5. Age distribution is similar to meningioma ranging from 7-81 years. Approximately 23% of cases originate in the spine which is the most common meningeal location. Histopathologic examination shows uniform spindle cell proliferation with various amount of collagen. CD34-positivity usually allows discrimination from schwannomas, meningiomas and hemangiopericytomas. A differential diagnosis is important because most of the solitary fibrous tumors usually behave in a benign fashion. In this study, we also showed CD117 (Kit) expression in a case of meningeal SFT. CD117-positivity can be a good strategy for treatment in malignant and recurrent cases. Further investigations are necessary for therapeutic implication of CD117-positivity in SFT.
Authors and Affiliations
Kemal Deniz, Olgun Kontas, Bullent Tucer, Ali Kurtsoy
Keywords
Related Articles
- EP ID EP118306
- DOI -
- Views 77
- Downloads 0
Neuropathological diagnosis of tumour and bridge card game. Some personal remarks and considerations (Letter to the Editor)
Distribution of metallothioneins in the brain neoplastic cells.
Metallothioneins (MT) are common proteins in animal tissues. These proteinstake part in the homeostasis of the ions of the metals which are necessary for the proper metabolismof the organism (zinc, copper), biosynthesis...
Autophagy – a basic mechanism and a potential role for neurodegeneration
Autophagy constitutes a fundamental survival strategy of cells; its disturbance contributes to the pathogenesis of cancer, liver and immune disease, pathogen infection, myopathies as well as neurodegenerative disorders s...
Inhibition of poly(ADP-ribose) polymerase activity protects hippocampal cells against morphological and ultrastructural alteration evoked by ischemia-reperfusion injury
Poly(ADP-ribose) polymerase 1 (PARP-1 EC 2.4.2.30) is a nuclear enzyme that plays an important role in cell survival and death. PARP is involved in DNA repair machinery, however, massive DNA damage leads to overactivatio...
Tauopathies: recent insights into old diseases
Neurofibrillary tangles are brain lesions that have been discovered at the beginning of the 20th century, using histological silver staining. Tangles are intra-neuronal hallmarks of a degenerating process: neurofibrillar...