Meta-analysis of efficacy and safety of Qianliexin capsule combined with western medicine in benign prostatic hyperplasia treatmen
Journal Title: TMR Integrative Medicine - Year 2021, Vol 5, Issue 20
Abstract
Objective: To systematically evaluate the efficacy and safety of Qianliexin capsule combined with western medicine in benign prostatic hyperplasia treatment. Methods: Randomized controlled trials of Qianliexin capsule combined with western medicine in the treatment of benign prostatic hyperplasia were searched from PubMed, the Cochrane Library, EMBASE, Web of Science, China National Knowledge Infrastructure, VIP, Wanfang and China Biomedical Literature Databases from establishment of the database to February 2021. Meta-analysis was performed using RevMan5.4 software after two researchers independently screened the literatures, extracted the data and evaluated the bias risks in the included studies according to the Cochrane Collaboration System Evaluator Manual. Results: 6 randomized controlled trials involving 1060 patients were included. Meta-analysis results showed that the treatment group was better than the control group in total effective rate (Relative Risk = 1.19, 95% Confidence Interval (1.10, 1.28), P < 0.00001), International Prostate Symptom Score (Mean Difference = -2.99, 95% confidence interval (-4.00, -1.99) , P < 0.00001), prostate volume (Mean Difference = -3.77, 95% Confidence Interval (-4.67, -2.86), P < 0.00001), postvoid residual urine volume (Mean Difference = -5.96, 95% Confidence Interval (-8.15, -3.77), P < 0.00001) and maximum urine flow rate (Mean Difference = 3.45, 95% Confidence Interval (2.53, 4.37), P < 0.00001). While there was no significant difference in the adverse effects rate (Relative Risk = 0.71, 95% Confidence Interval (0.33, 1.56), P = 0.40) between the treatment group and the control group. Conclusion: Qianliexin capsule combined with western medicine in the treatment of benign prostatic hyperplasia showed good efficacy and high safety. However, more high-quality and large-sample studies are needed to confirm the above conclusions.
Authors and Affiliations
Sheng-Nan Wang, Yi-Hua Fan, Shan Lin, Jin-Rui Wei, Sheng-Xuan Zhao, Qiao Liu, Kai Zhong
Keywords
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- EP ID EP697539
- DOI 10.53388/TMRIM202105020
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