METHOD DEVELOPMENT AND VALIDATION OF COMBINED TABLET DOSAGE FORM OF EMTRICITABINE AND TENOFOVIR DISPROXIL FUMERATE BY ULTRAVIOLET SPECTROSCOPY
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 12
Abstract
In this study an attempt was made to provide newer simple, accurate and less time consuming Ultraviolet (UV) method for determination of Emtricitabine (EMT) and Tenofovir disproxil fumerate (TDF) in tablet dosage form. The absorption maxima of both drugs were found at 282nm and 261nm and obeyed Beer’s law in the range of 5-25μg/ml (Y=0.020-0.005; r2 = 0.999) and 5-25μg/ml (Y=0.021x+0.007; r2 = 0.999) respectively for EMT and TDF and methanol is used as a solvent system. Accuracy and reproducibility of the proposed method was statistically validated by recovery studies. This method is found to be precise and accurate and can easily be employed in the laboratory for the routine estimation of drugs.
Authors and Affiliations
lavanya Budagam , Hariprasad Perumalla , Venkatapraveen Allumellu , Prasanna lakshmi, Dhanalakshmi
Keywords
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