Method Development and Validation of Related Substances by HPLC for Analysis of Valacyclovir Hcl in valacyclovir Hcl Tablet Formulations
Journal Title: International Journal of Pharmacy and Analytical Research - Year 2014, Vol 3, Issue 2
Abstract
A simple, sensitive, and precise high performance liquid chromatographic method for the impurities profiling of Valacyclovir Hcl tablets has been developed, validated and used for the determination of impurities in commercial pharmaceutical products. The Impurities were well separated on a Zorbax SB Phenyl column (250 mm X 4.6 mm, 5μm) by the gradient program using Triflouro acetic acid, Acetonitrile, methanole Methanolic HCl at a flow rate of 1.0 mL min-1 with detection wavelength at 254 nm. The developed method was found to be specific, precise, linear, accurate. LOQ Values for all the known impurities were below reporting thresholds.
Authors and Affiliations
B Bhagyalaxmi
Keywords
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