Method development and validation of RP-HPLC Method for determination of new Antipsychotic agent in Paliperidone Palmitate bulk drug
Journal Title: International Journal of Novel Trends in Pharmaceutical Sciences - Year 2014, Vol 4, Issue 5
Abstract
A simple, precise, rapid ,reproducible, accurate and stability indicating RP-HPLC method has been developed for the determination of new antipsychotic agent paliperidone in pharmaceutical formulation. zorbax –SB-phenyl, 150x4.6mm; 3.5µm particle size column was used with variable wavelength UV detector. The mobile phase consisting of PH 4 Buffer and Acetonitrile 80:20 v/v was used. The flow rate was 1 ml/min and the effluent was monitored at 238 nm. The retention time of drug was 0.9. The method was linear over the concentration range of 1.0 mg/ml. The method precision for the determination of assay was below 2%RSD. The percentage recovery of paliperidone was 85-115%. The validation of method was carried out utilizing ICH Q2 (R1) guidelines.
Authors and Affiliations
G. Swarnalatha , B. Vijayakumar , D. Jothieswari , P. Jaya Chandra Reddy , M. Mohankumar
Keywords
Related Articles
- EP ID EP107241
- DOI -
- Views 74
- Downloads 0
Evaluation of cardioprotective activity of Pandanus odoratissimus leaves against isoproterenol induced myocardial infarction in albino rats
Cardiotoxicity is the occurance of heart electrophysiological dysfunction or muscle damage.In the present study Pandanus odoratissimus was used as Cardioprotective agent against Isoproterenol induced Myocardial Infarctio...
Marine Organism: Lead Compounds and as a Source of New Antiviral Agents
Natural product lead compounds from various marine sources have often been found to be promising pharmaceutical agents. Several of them have successfully been approved as antiviral agents for clinical use or have been ad...
Formulation and evaluation of transdermal patch containing amphotericin B
Transdermal drug delivery system are topically administered medicaments in the form of patches that deliver drugs for systemic effects at a predetermined and controlled rate. These devices allow for pharmaceuticals to be...
Comparative Docking Studies on Neurological and Psychological disorders Genes (BDNF and CLCN2) using Cheminformatics Protocols
Aim: The current work performed is a target based approach for drug therapy. This strategic approach was tested for the selected diseases such as Psychology and Epilepsy disorder. Methods: The advanced software tools and...
Insilco Gene Expression Profiling and Comparative Analysis of Legionellosis
Legionellosis is the major problem in the world but the treatment of the disease is very difficult. The disease caused gene is Legionella and the bacterium is Legionella pneumophila. Kegg is used for the Legionellosis pa...